A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants

David C A Candy; Marleen T J Van Ampting; Manon M Oude Nijhuis; Harm Wopereis; Assad M Butt; Diego G Peroni; Yvan Vandenplas; Adam T Fox; Neil Shah; Christina E West; Johan Garssen; Lucien F Harthoorn; Jan Knol; Louise J Michaelis

doi:10.1038/pr.2017.270

A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants

David C A Candy, Marleen T J Van Ampting^*, Manon M Oude Nijhuis, Harm Wopereis, Assad M Butt, Diego G Peroni, Yvan Vandenplas, Adam T Fox, Neil Shah, Christina E West, Johan Garssen, Lucien F Harthoorn, Jan Knol, Louise J Michaelis

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow's milk allergy (CMA).

METHODS: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age matched healthy breastfed infants were used as reference (HBR) for primary outcomes. CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.

RESULTS: Thirty-five (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, median percentage of bifidobacteria was higher in test group vs control group (35.4 vs. 9.7%, respectively P<0.001), whereas ER/CC was lower (9.5 vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55 and 6.5%, respectively.

CONCLUSION: AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.270.

Original language	English
Pages (from-to)	677–686
Number of pages	10
Journal	Pediatric Research
Volume	83
DOIs	https://doi.org/10.1038/pr.2017.270
Publication status	Published - 2018

Access to Document

10.1038/pr.2017.270Licence: CC BY

A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infantsFinal published version, 716 KBLicence: CC BY

Cite this

Candy, D. C. A., Van Ampting, M. T. J., Nijhuis, M. M. O., Wopereis, H., Butt, A. M., Peroni, D. G., Vandenplas, Y., Fox, A. T., Shah, N., West, C. E., Garssen, J., Harthoorn, L. F., Knol, J., & Michaelis, L. J. (2018). A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatric Research, 83, 677–686. https://doi.org/10.1038/pr.2017.270

@article{7ec9dcc34cd64f7cafe6cc9190ac9362,

title = "A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants",

abstract = "BACKGROUND: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow's milk allergy (CMA).METHODS: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age matched healthy breastfed infants were used as reference (HBR) for primary outcomes. CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.RESULTS: Thirty-five (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, median percentage of bifidobacteria was higher in test group vs control group (35.4 vs. 9.7%, respectively P<0.001), whereas ER/CC was lower (9.5 vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55 and 6.5%, respectively.CONCLUSION: AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.270.",

author = "Candy, {David C A} and {Van Ampting}, {Marleen T J} and Nijhuis, {Manon M Oude} and Harm Wopereis and Butt, {Assad M} and Peroni, {Diego G} and Yvan Vandenplas and Fox, {Adam T} and Neil Shah and West, {Christina E} and Johan Garssen and Harthoorn, {Lucien F} and Jan Knol and Michaelis, {Louise J}",

year = "2018",

doi = "10.1038/pr.2017.270",

language = "English",

volume = "83",

pages = "677–686",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Springer Nature",

}

Candy, DCA, Van Ampting, MTJ, Nijhuis, MMO, Wopereis, H, Butt, AM, Peroni, DG, Vandenplas, Y, Fox, AT, Shah, N, West, CE, Garssen, J, Harthoorn, LF, Knol, J & Michaelis, LJ 2018, 'A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants', Pediatric Research, vol. 83, pp. 677–686. https://doi.org/10.1038/pr.2017.270

TY - JOUR

T1 - A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants

AU - Candy, David C A

AU - Van Ampting, Marleen T J

AU - Nijhuis, Manon M Oude

AU - Wopereis, Harm

AU - Butt, Assad M

AU - Peroni, Diego G

AU - Vandenplas, Yvan

AU - Fox, Adam T

AU - Shah, Neil

AU - West, Christina E

AU - Garssen, Johan

AU - Harthoorn, Lucien F

AU - Knol, Jan

AU - Michaelis, Louise J

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow's milk allergy (CMA).METHODS: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age matched healthy breastfed infants were used as reference (HBR) for primary outcomes. CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.RESULTS: Thirty-five (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, median percentage of bifidobacteria was higher in test group vs control group (35.4 vs. 9.7%, respectively P<0.001), whereas ER/CC was lower (9.5 vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55 and 6.5%, respectively.CONCLUSION: AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.270.

AB - BACKGROUND: Prebiotics and probiotics (synbiotics) can modify gut microbiota and have potential in allergy management when combined with amino acid-based formula (AAF) for infants with cow's milk allergy (CMA).METHODS: This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF including synbiotic blend on percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) in feces from infants with suspected non-IgE-mediated CMA. Feces from age matched healthy breastfed infants were used as reference (HBR) for primary outcomes. CMA subjects were randomized and received test or control formula for 8 weeks. Test formula was a hypoallergenic, nutritionally complete AAF including a prebiotic blend of fructo-oligosaccharides and the probiotic strain Bifidobacterium breve M-16V. Control formula was AAF without synbiotics.RESULTS: Thirty-five (test) and 36 (control) subjects were randomized; HBR included 51 infants. At week 8, median percentage of bifidobacteria was higher in test group vs control group (35.4 vs. 9.7%, respectively P<0.001), whereas ER/CC was lower (9.5 vs. 24.2%, respectively; P<0.001). HBR levels of bifidobacteria and ER/CC were 55 and 6.5%, respectively.CONCLUSION: AAF including specific synbiotics, which results in levels of bifidobacteria and ER/CC approximating levels in HBR group, improves the fecal microbiota of infants with suspected non-IgE-mediated CMA.Pediatric Research accepted article preview online, 20 November 2017. doi:10.1038/pr.2017.270.

U2 - 10.1038/pr.2017.270

DO - 10.1038/pr.2017.270

M3 - Article

C2 - 29155807

SN - 0031-3998

VL - 83

SP - 677

EP - 686

JO - Pediatric Research

JF - Pediatric Research

ER -

A synbiotic-containing amino acid-based formula improves gut microbiota in non-IgE-mediated allergic infants

Abstract

Access to Document

Fingerprint

Cite this