A role for Bicaudal-D2 in radial cerebellar granule cell migration

Dick Jaarsma, Robert van den Berg, Phebe S Wulf, Susan van Erp, Nanda Keijzer, Max A Schlager, Esther de Graaff, Chris I De Zeeuw, R Jeroen Pasterkamp, Anna Akhmanova, Casper C Hoogenraad

Research output: Contribution to journalArticleAcademicpeer-review


Bicaudal-D (BICD) belongs to an evolutionary conserved family of dynein adaptor proteins. It was first described in Drosophila as an essential factor in fly oogenesis and embryogenesis. Missense mutations in a human BICD homologue, BICD2, have been linked to a dominant mild early onset form of spinal muscular atrophy. Here we further examine the in vivo function of BICD2 in Bicd2 knockout mice. BICD2-deficient mice develop disrupted laminar organization of cerebral cortex and the cerebellum, pointing to impaired radial neuronal migration. Using astrocyte and granule cell specific inactivation of BICD2, we show that the cerebellar migration defect is entirely dependent upon BICD2 expression in Bergmann glia cells. Proteomics analysis reveals that Bicd2 mutant mice have an altered composition of extracellular matrix proteins produced by glia cells. These findings demonstrate an essential non-cell-autonomous role of BICD2 in neuronal cell migration, which might be connected to cargo trafficking pathways in glia cells.

Original languageEnglish
Pages (from-to)3411
JournalNature Communications [E]
Publication statusPublished - 2014


  • Animals
  • Astrocytes
  • Blotting, Western
  • Brain
  • Cell Movement
  • Cerebellum
  • Cerebral Cortex
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Microscopy, Confocal
  • Microtubule-Associated Proteins
  • Neuroglia
  • Neurons
  • Rats
  • Time Factors


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