TY - JOUR
T1 - A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone
AU - Dinkelaar, Jasper
AU - Duivenvoorden, Boudewijn A.
AU - Wennekes, Tom
AU - Overkleeft, Herman S.
AU - Boot, Rolf G.
AU - Aerts, Johannes M. F. G.
AU - Codee, Jeroen D. C.
AU - van der Marel, Gijs A.
PY - 2010
Y1 - 2010
N2 - To meet the increasing clinical demand for the diagnostic agent (4′-deoxychitobiosyl)-4-methylumbelliferone, a flexible and scalable route of synthesis is needed. In this paper such a route is presented. The key to the route is the use of a partially protected thiophenyl glucosamine as starting material for the preparation of both the reducing and nonreducing end building blocks of the 4′-deoxychitobiose disaccharide.
AB - To meet the increasing clinical demand for the diagnostic agent (4′-deoxychitobiosyl)-4-methylumbelliferone, a flexible and scalable route of synthesis is needed. In this paper such a route is presented. The key to the route is the use of a partially protected thiophenyl glucosamine as starting material for the preparation of both the reducing and nonreducing end building blocks of the 4′-deoxychitobiose disaccharide.
U2 - 10.1002/ejoc.201000080
DO - 10.1002/ejoc.201000080
M3 - Article
SN - 0075-4617
VL - 2010
SP - 2565
EP - 2570
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
IS - 13
ER -