A perspective on the developmental toxicity of inhaled nanoparticles

Karin Sørig Hougaard; Luisa Campagnolo; Pascale Chavatte-Palmer; Anne Tarrade; Delphine Rousseau-Ralliard; Sarah Valentino; Margriet V D Z Park; Wim H de Jong; Gerrit Wolterink; Aldert H Piersma; Bryony L Ross; Gary R Hutchison; Jitka Stilund Hansen; Ulla Vogel; Petra Jackson; Rémy Slama; Antonio Pietroiusti; Flemming R Cassee

doi:10.1016/j.reprotox.2015.05.015

A perspective on the developmental toxicity of inhaled nanoparticles

Karin Sørig Hougaard, Luisa Campagnolo, Pascale Chavatte-Palmer, Anne Tarrade, Delphine Rousseau-Ralliard, Sarah Valentino, Margriet V D Z Park, Wim H de Jong, Gerrit Wolterink, Aldert H Piersma, Bryony L Ross, Gary R Hutchison, Jitka Stilund Hansen, Ulla Vogel, Petra Jackson, Rémy Slama, Antonio Pietroiusti, Flemming R Cassee

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

Original language	English
Pages (from-to)	118-40
Number of pages	23
Journal	Reproductive Toxicology
Volume	56
DOIs	https://doi.org/10.1016/j.reprotox.2015.05.015
Publication status	Published - 15 Aug 2015

Keywords

Nanoparticles
Nanomaterial
Ultrafine particles
Developmental toxicity
Reproductive toxicity
Inhalation
Instillation
Pregnancy

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10.1016/j.reprotox.2015.05.015

inhaledFinal published version, 1.23 MBLicence: Taverne

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Hougaard, K. S., Campagnolo, L., Chavatte-Palmer, P., Tarrade, A., Rousseau-Ralliard, D., Valentino, S., Park, M. V. D. Z., de Jong, W. H., Wolterink, G., Piersma, A. H., Ross, B. L., Hutchison, G. R., Hansen, J. S., Vogel, U., Jackson, P., Slama, R., Pietroiusti, A., & Cassee, F. R. (2015). A perspective on the developmental toxicity of inhaled nanoparticles. Reproductive Toxicology, 56, 118-40. https://doi.org/10.1016/j.reprotox.2015.05.015

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abstract = "This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.",

keywords = "Nanoparticles, Nanomaterial, Ultrafine particles, Developmental toxicity, Reproductive toxicity, Inhalation, Instillation, Pregnancy",

author = "Hougaard, {Karin S{\o}rig} and Luisa Campagnolo and Pascale Chavatte-Palmer and Anne Tarrade and Delphine Rousseau-Ralliard and Sarah Valentino and Park, {Margriet V D Z} and {de Jong}, {Wim H} and Gerrit Wolterink and Piersma, {Aldert H} and Ross, {Bryony L} and Hutchison, {Gary R} and Hansen, {Jitka Stilund} and Ulla Vogel and Petra Jackson and R{\'e}my Slama and Antonio Pietroiusti and Cassee, {Flemming R}",

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doi = "10.1016/j.reprotox.2015.05.015",

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Hougaard, KS, Campagnolo, L, Chavatte-Palmer, P, Tarrade, A, Rousseau-Ralliard, D, Valentino, S, Park, MVDZ, de Jong, WH, Wolterink, G, Piersma, AH, Ross, BL, Hutchison, GR, Hansen, JS, Vogel, U, Jackson, P, Slama, R, Pietroiusti, A & Cassee, FR 2015, 'A perspective on the developmental toxicity of inhaled nanoparticles', Reproductive Toxicology, vol. 56, pp. 118-40. https://doi.org/10.1016/j.reprotox.2015.05.015

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AU - Hougaard, Karin Sørig

AU - Campagnolo, Luisa

AU - Chavatte-Palmer, Pascale

AU - Tarrade, Anne

AU - Rousseau-Ralliard, Delphine

AU - Valentino, Sarah

AU - Park, Margriet V D Z

AU - de Jong, Wim H

AU - Wolterink, Gerrit

AU - Piersma, Aldert H

AU - Ross, Bryony L

AU - Hutchison, Gary R

AU - Hansen, Jitka Stilund

AU - Vogel, Ulla

AU - Jackson, Petra

AU - Slama, Rémy

AU - Pietroiusti, Antonio

AU - Cassee, Flemming R

PY - 2015/8/15

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AB - This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP) may constitute a hazard to pregnancy and fetal development, primarily based on experimental animal studies of NP and air pollution particles. Overall, it is plausible that NP may translocate from the respiratory tract to the placenta and fetus, but also that adverse effects may occur secondarily to maternal inflammatory responses. The limited database describes several organ systems in the offspring to be potentially sensitive to maternal inhalation of particles, but large uncertainties exist about the implications for embryo-fetal development and health later in life. Clearly, the potential for hazard remains to be characterized. Considering the increased production and application of nanomaterials and related consumer products a testing strategy for NP should be established. Due to large gaps in data, significant amounts of groundwork are warranted for a testing strategy to be established on a sound scientific basis.

KW - Nanoparticles

KW - Nanomaterial

KW - Ultrafine particles

KW - Developmental toxicity

KW - Reproductive toxicity

KW - Inhalation

KW - Instillation

KW - Pregnancy

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DO - 10.1016/j.reprotox.2015.05.015

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SN - 0890-6238

VL - 56

SP - 118

EP - 140

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

A perspective on the developmental toxicity of inhaled nanoparticles

Abstract

Keywords

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