A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Jennifer Mattock; Marie Anne Chattaway; Hassan Hartman; Timothy J Dallman; Anthony M Smith; Karen Keddy; Liljana Petrovska; Emma J Manners; Sanelisiwe T Duze; Shannon Smouse; Nomsa Tau; Ruth Timme; Dave J Baker; Alison E Mather; John Wain; Gemma C Langridge

doi:10.3201/eid3004.231031

A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Jennifer Mattock, Marie Anne Chattaway, Hassan Hartman, Timothy J Dallman, Anthony M Smith, Karen Keddy, Liljana Petrovska, Emma J Manners, Sanelisiwe T Duze, Shannon Smouse, Nomsa Tau, Ruth Timme, Dave J Baker, Alison E Mather, John Wain, Gemma C Langridge

UK Health Security Agency

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.

Original language	English
Pages (from-to)	701-710
Number of pages	10
Journal	Emerging Infectious Diseases
Volume	30
Issue number	4
DOIs	https://doi.org/10.3201/eid3004.231031
Publication status	Published - Apr 2024
Externally published	Yes

Keywords

Animals
Anti-Bacterial Agents/pharmacology
Drug Resistance, Multiple, Bacterial/genetics
Humans
One Health
Poultry
Salmonella enterica
Salmonella/genetics
Serogroup

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10.3201/eid3004.231031

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Mattock, J., Chattaway, M. A., Hartman, H., Dallman, T. J., Smith, A. M., Keddy, K., Petrovska, L., Manners, E. J., Duze, S. T., Smouse, S., Tau, N., Timme, R., Baker, D. J., Mather, A. E., Wain, J., & Langridge, G. C. (2024). A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen. Emerging Infectious Diseases, 30(4), 701-710. https://doi.org/10.3201/eid3004.231031

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title = "A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen",

abstract = "Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.",

keywords = "Animals, Anti-Bacterial Agents/pharmacology, Drug Resistance, Multiple, Bacterial/genetics, Humans, One Health, Poultry, Salmonella enterica, Salmonella/genetics, Serogroup",

author = "Jennifer Mattock and Chattaway, {Marie Anne} and Hassan Hartman and Dallman, {Timothy J} and Smith, {Anthony M} and Karen Keddy and Liljana Petrovska and Manners, {Emma J} and Duze, {Sanelisiwe T} and Shannon Smouse and Nomsa Tau and Ruth Timme and Baker, {Dave J} and Mather, {Alison E} and John Wain and Langridge, {Gemma C}",

year = "2024",

month = apr,

doi = "10.3201/eid3004.231031",

language = "English",

volume = "30",

pages = "701--710",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

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Mattock, J, Chattaway, MA, Hartman, H, Dallman, TJ, Smith, AM, Keddy, K, Petrovska, L, Manners, EJ, Duze, ST, Smouse, S, Tau, N, Timme, R, Baker, DJ, Mather, AE, Wain, J & Langridge, GC 2024, 'A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen', Emerging Infectious Diseases, vol. 30, no. 4, pp. 701-710. https://doi.org/10.3201/eid3004.231031

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T1 - A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

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AU - Chattaway, Marie Anne

AU - Hartman, Hassan

AU - Dallman, Timothy J

AU - Smith, Anthony M

AU - Keddy, Karen

AU - Petrovska, Liljana

AU - Manners, Emma J

AU - Duze, Sanelisiwe T

AU - Smouse, Shannon

AU - Tau, Nomsa

AU - Timme, Ruth

AU - Baker, Dave J

AU - Mather, Alison E

AU - Wain, John

AU - Langridge, Gemma C

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N2 - Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.

AB - Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.

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KW - Anti-Bacterial Agents/pharmacology

KW - Drug Resistance, Multiple, Bacterial/genetics

KW - Humans

KW - One Health

KW - Poultry

KW - Salmonella enterica

KW - Salmonella/genetics

KW - Serogroup

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DO - 10.3201/eid3004.231031

M3 - Article

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SN - 1080-6040

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JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 4

ER -

A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

Abstract

Keywords

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