Abstract
A common assumption is that genes essential to a species survival must be deeply conserved. Kruger et al. report how two newly acquired X-linked gene families, Slx and Slxl1, evolved from an autosomal single-copy gene, massively duplicated, became essential for male fertility, and mediated the sex ratio of offspring by gene copy-number changes.
| Original language | English |
|---|---|
| Pages (from-to) | 3699-3706.e5 |
| Journal | Current Biology |
| Volume | 29 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 4 Nov 2019 |
Funding
We acknowledge Cincinnati Children’s Hospital Medical Center Transgenic Animal and Genome Editing Core for mutant mouse production, Celvie Yuan and Yang Yu for their assistance with ROSI experiments, the University of Michigan Flow Cytometry Shared Resource Laboratory for FACS, DNA Sequencing Core for Sanger, Next Generation Sequencing, Venkatesha Basrur at the Proteomics Resource facility for mass spectrometry, and Cancer Center Tissue Core for generating testis histological sections. We thank D. Ginsburg for sharing EIIa -Cre mice. We thank M. Arlt, S. Kalantry, J. Moran, C. Swanepoel, and Y. Yamashita for their comments. This work was supported by NIH grants HD064753 and HD094736 to J.L.M. and T32GM007544 to A.N.K. and a National Science Foundation Graduate Research Fellowship DGE 1256260 to A.N.K.
Keywords
- gene dosage
- male infertility
- meiotic drive
- X chromosome
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