TY - JOUR
T1 - A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation
AU - Augurio, Adriana
AU - Cortelletti, Paolo
AU - Tognato, Riccardo
AU - Rios, Anne
AU - Levato, Riccardo
AU - Malda, Jos
AU - Alini, Mauro
AU - Eglin, David
AU - Giancane, Gabriele
AU - Speghini, Adolfo
AU - Serra, Tiziano
PY - 2020/3
Y1 - 2020/3
N2 - Herein, the fabrication of multi‐responsive and hierarchically organized nanomaterial using core‐shell SrF2 upconverting nanoparticles, doped with Yb3+, Tm3+, Nd3+ incorporated into gelatin methacryloyl matrix, is reported. Upon 800 nm excitation, deep monitoring of 3D‐printed constructs is demonstrated. Addition of magnetic self‐assembly of iron oxide nanoparticles within the hydrogel provides anisotropic structuration from the nano‐ to the macro‐scale and magnetic responsiveness permitting remote manipulation. The present study provides a new strategy for the fabrication of a novel highly organized multi‐responsive material using additive manufacturing, which can have important implications in biomedicine.
AB - Herein, the fabrication of multi‐responsive and hierarchically organized nanomaterial using core‐shell SrF2 upconverting nanoparticles, doped with Yb3+, Tm3+, Nd3+ incorporated into gelatin methacryloyl matrix, is reported. Upon 800 nm excitation, deep monitoring of 3D‐printed constructs is demonstrated. Addition of magnetic self‐assembly of iron oxide nanoparticles within the hydrogel provides anisotropic structuration from the nano‐ to the macro‐scale and magnetic responsiveness permitting remote manipulation. The present study provides a new strategy for the fabrication of a novel highly organized multi‐responsive material using additive manufacturing, which can have important implications in biomedicine.
U2 - 10.1002/aisy.201900105
DO - 10.1002/aisy.201900105
M3 - Article
SN - 2640-4567
VL - 2
JO - Advanced Intelligent Systems
JF - Advanced Intelligent Systems
IS - 3
M1 - 1900105
ER -