A Multifunctional Nanocomposite Hydrogel for Endoscopic Tracking and Manipulation

Adriana Augurio, Paolo Cortelletti, Riccardo Tognato, Anne Rios, Riccardo Levato, Jos Malda, Mauro Alini, David Eglin, Gabriele Giancane, Adolfo Speghini, Tiziano Serra

Research output: Contribution to journalArticleAcademicpeer-review


Herein, the fabrication of multi‐responsive and hierarchically organized nanomaterial using core‐shell SrF2 upconverting nanoparticles, doped with Yb3+, Tm3+, Nd3+ incorporated into gelatin methacryloyl matrix, is reported. Upon 800 nm excitation, deep monitoring of 3D‐printed constructs is demonstrated. Addition of magnetic self‐assembly of iron oxide nanoparticles within the hydrogel provides anisotropic structuration from the nano‐ to the macro‐scale and magnetic responsiveness permitting remote manipulation. The present study provides a new strategy for the fabrication of a novel highly organized multi‐responsive material using additive manufacturing, which can have important implications in biomedicine.
Original languageEnglish
Article number1900105
Number of pages8
JournalAdvanced Intelligent Systems
Issue number3
Publication statusPublished - Mar 2020


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