A mixture of prebiotic oligosaccharides reduces immunoglobulin κ and λ free light-chain levels in infants at high risk for allergy

B. Schouten, B. Van Esch, G. Hofman, G. Moro, G. Boehm, S. Arslanoglu, L. Willemsen, L. Knippels, J. Garssen

Research output: Contribution to journalMeeting AbstractAcademic

Abstract

Background and Aim: There is evidence that the intestinal microbiota play an important role in the development of the immune system of neonates. Prebiotic oligosaccharides influence the intestinal microbiota and can positively modulate the postnatal development of the immune system. In previous studies it has been shown that the prebiotic mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides in a ratio 9:1 (Immunofortis) reduces the incidence of atopic dermatitis (Arch Dis Child 2006;91:814-9; Allergy 2008;May 27 [Epub ahead of print]). Recently it was shown that Ig free light chains (Ig-fLC) in plasma might be a biomarker for atopic dermatitis, here the involvement of k and l Ig-fLC in the modulation of infants fed a prebiotic diet was studied. Methods: In a double-blind, randomized placebo-controlled trial; infants received a hypoallergenic whey formula with either 8 g/L of the prebiotics (n = 34) or maltodextrine (n = 40) as a placebo for 6 months. At the age of 6 months plasma samples were collected from the infants. Total plasma levels of κ and λ Ig-fLC were analyzed using ELISA. Results: Total plasma levels of κ and λ Ig-fLC were lowered in infants on the prebiotic oligosaccharide mixture compared to the placebo (Ig-fLC κ 7.5±0.4 vs 5.7±0.4μg/mL and Ig-fLC λ 8.8±0.6 vs 6.3±0.4μg/ mL; P = 0.0009 for both κ and λ Ig-fLC) (Fig. 1). Conclusions: These data demonstrate that the studied prebiotic mixture is capable of lowering the κ and λ IgfLC plasma levels in infants at high risk for allergy (Graph presented) indicating their capacity to modulate the postnatal development of the immune system and their possible role in allergy prevention.
Original languageEnglish
Pages (from-to)72-73
Number of pages2
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume48
DOIs
Publication statusPublished - 1 May 2009
EventEuropean Society for Paediatric Gastroenterology, Hepatology and Nutrition Annual Meeting - Budapest, Hungary
Duration: 3 Jun 20096 Jun 2009

Keywords

  • immunoglobulin
  • prebiotic agent
  • oligosaccharide
  • placebo
  • biological marker
  • fructose oligosaccharide
  • galactose oligosaccharide
  • infant
  • society
  • gastroenterology
  • allergy
  • light chain
  • risk
  • nutrition
  • immune system
  • blood level
  • postnatal development
  • atopic dermatitis
  • plasma
  • intestine flora
  • child
  • diet
  • modulation
  • controlled study
  • whey
  • newborn
  • prevention
  • enzyme linked immunosorbent assay

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