A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

Ke Wang; Frédéric Friscourt; Chaofeng Dai; Lifang Wang; Yueqin Zheng; Geert-Jan Boons; Siming Wang; Binghe Wang

doi:10.1016/j.bmcl.2016.02.069

A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

Ke Wang
, Frédéric Friscourt
, Chaofeng Dai
, Lifang Wang
, Yueqin Zheng
, Geert-Jan Boons
, Siming Wang
, Binghe Wang

extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.

Original language	English
Pages (from-to)	1651-1654
Number of pages	4
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2016.02.069
Publication status	Published - 1 Apr 2016
Externally published	Yes

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10.1016/j.bmcl.2016.02.069

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title = "A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides",

abstract = "Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.",

author = "Ke Wang and Fr{\'e}d{\'e}ric Friscourt and Chaofeng Dai and Lifang Wang and Yueqin Zheng and Geert-Jan Boons and Siming Wang and Binghe Wang",

note = "Published by Elsevier Ltd.",

year = "2016",

month = apr,

day = "1",

doi = "10.1016/j.bmcl.2016.02.069",

language = "English",

volume = "26",

pages = "1651--1654",

journal = "Bioorganic \& Medicinal Chemistry Letters",

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TY - JOUR

T1 - A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

AU - Wang, Ke

AU - Friscourt, Frédéric

AU - Dai, Chaofeng

AU - Wang, Lifang

AU - Zheng, Yueqin

AU - Boons, Geert-Jan

AU - Wang, Siming

AU - Wang, Binghe

N1 - Published by Elsevier Ltd.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.

AB - Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.

U2 - 10.1016/j.bmcl.2016.02.069

DO - 10.1016/j.bmcl.2016.02.069

M3 - Article

C2 - 26944613

SN - 0960-894X

VL - 26

SP - 1651

EP - 1654

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 7

ER -

A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

Abstract

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