A metal-free turn-on fluorescent probe for the fast and sensitive detection of inorganic azides

Ke Wang, Frédéric Friscourt, Chaofeng Dai, Lifang Wang, Yueqin Zheng, Geert-Jan Boons, Siming Wang, Binghe Wang

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Sodium azide is toxic and widely used in agricultural, commercial products, and research laboratories. Thus it is of a significant environmental concern and there is a need for the development of a rapid detection method. A fluorogenic dibenzylcyclooctyne derivative (Fl-DIBO) is herein described as a fluorescent probe for the rapid detection of inorganic azide via Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC). Fl-DIBO was found to be highly selective toward NaN3 in comparison to other common anions with good sensitivity and detection limit of 10μM.

Original languageEnglish
Pages (from-to)1651-1654
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume26
Issue number7
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

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