A human monoclonal antibody blocking SARS-CoV-2 infection

Chunyan Wang, Wentao Li, Dubravka Drabek, Nisreen M A Okba, Rien van Haperen, Albert D M E Osterhaus, Frank J M van Kuppeveld, Bart L Haagmans, Frank Grosveld, Berend-Jan Bosch

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.

Original languageEnglish
Article number2251
Pages (from-to)1-6
Number of pages6
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 2020

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