A growth-rate composition formula for the growth of E.coli on co-utilized carbon substrates

Rutger Hermsen, Hiroyuki Okano, Conghui You, Nicole Werner, Terence Hwa

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by Escherichia coli cells through cAMP-Crp signaling, we show that this signaling system responds to the total carbon-uptake flux when substrates are co-utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.

Original languageEnglish
JournalMolecular Systems Biology [E]
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2015

Keywords

  • Algorithms
  • Carbon
  • Catabolite Repression
  • Culture Media
  • Cyclic AMP
  • Cyclic AMP Receptor Protein
  • Escherichia coli
  • Escherichia coli Proteins
  • Feedback, Physiological
  • Genes, Reporter

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