A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai; Zhaoming Wang; Sonja I Berndt; Christine F Skibola; Susan L Slager; Silvia de Sanjose; Mads Melbye; Bengt Glimelius; Paige M Bracci; Lucia Conde; Brenda M Birmann; Sophia S Wang; Angela R Brooks-Wilson; Qing Lan; Paul I W de Bakker; Roel C H Vermeulen; Carol Portlock; Stephen M Ansell; Brian K Link; Jacques Riby; Kari E North; Jian Gu; Henrik Hjalgrim; Wendy Cozen; Nikolaus Becker; Lauren R Teras; John J Spinelli; Jenny Turner; Yawei Zhang; Mark P Purdue; Graham G Giles; Rachel S Kelly; Anne Zeleniuch-Jacquotte; Maria Grazia Ennas; Alain Monnereau; Kimberly A Bertrand; Demetrius Albanes; Tracy Lightfoot; Meredith Yeager; Charles C Chung; Laurie Burdett; Amy Hutchinson; Charles Lawrence; Rebecca Montalvan; Liming Liang; Jinyan Huang; Baoshan Ma; Danylo J Villano; Ann Maria; Marina Corines; Tinu Thomas; Anne J Novak; Ahmet Dogan; Mark Liebow; Carrie A Thompson; Thomas E Witzig; Thomas M Habermann; George J Weiner; Martyn T Smith; Elizabeth A Holly; Rebecca D Jackson; Lesley F Tinker; Yuanqing Ye; Hans-Olov Adami; Karin E Smedby; Anneclaire J De Roos; Patricia Hartge; Lindsay M Morton; Richard K Severson; Yolanda Benavente; Paolo Boffetta; Paul Brennan; Lenka Foretova; Marc Maynadie; James McKay; Anthony Staines; W Ryan Diver; Claire M Vajdic; Bruce K Armstrong; Anne Kricker; Tongzhang Zheng; Theodore R Holford; Gianluca Severi; Paolo Vineis; Giovanni M Ferri; Rosalia Ricco; Lucia Miligi; Jacqueline Clavel; Edward Giovannucci; Peter Kraft; Jarmo Virtamo; Alex Smith; Eleanor Kane; Eve Roman; Brian C H Chiu; Joseph F Fraumeni; Xifeng Wu; James R Cerhan; Kenneth Offit; Stephen J Chanock; Nathaniel Rothman; Alexandra Nieters

doi:10.1038/ncomms6751

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

Joseph Vijai, Zhaoming Wang, Sonja I Berndt, Christine F Skibola, Susan L Slager, Silvia de Sanjose, Mads Melbye, Bengt Glimelius, Paige M Bracci, Lucia Conde, Brenda M Birmann, Sophia S Wang, Angela R Brooks-Wilson, Qing Lan, Paul I W de Bakker, Roel C H Vermeulen, Carol Portlock, Stephen M Ansell, Brian K Link, Jacques RibyKari E North, Jian Gu, Henrik Hjalgrim, Wendy Cozen, Nikolaus Becker, Lauren R Teras, John J Spinelli, Jenny Turner, Yawei Zhang, Mark P Purdue, Graham G Giles, Rachel S Kelly, Anne Zeleniuch-Jacquotte, Maria Grazia Ennas, Alain Monnereau, Kimberly A Bertrand, Demetrius Albanes, Tracy Lightfoot, Meredith Yeager, Charles C Chung, Laurie Burdett, Amy Hutchinson, Charles Lawrence, Rebecca Montalvan, Liming Liang, Jinyan Huang, Baoshan Ma, Danylo J Villano, Ann Maria, Marina Corines, Tinu Thomas, Anne J Novak, Ahmet Dogan, Mark Liebow, Carrie A Thompson, Thomas E Witzig, Thomas M Habermann, George J Weiner, Martyn T Smith, Elizabeth A Holly, Rebecca D Jackson, Lesley F Tinker, Yuanqing Ye, Hans-Olov Adami, Karin E Smedby, Anneclaire J De Roos, Patricia Hartge, Lindsay M Morton, Richard K Severson, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, W Ryan Diver, Claire M Vajdic, Bruce K Armstrong, Anne Kricker, Tongzhang Zheng, Theodore R Holford, Gianluca Severi, Paolo Vineis, Giovanni M Ferri, Rosalia Ricco, Lucia Miligi, Jacqueline Clavel, Edward Giovannucci, Peter Kraft, Jarmo Virtamo, Alex Smith, Eleanor Kane, Eve Roman, Brian C H Chiu, Joseph F Fraumeni, Xifeng Wu, James R Cerhan, Kenneth Offit, Stephen J Chanock, Nathaniel Rothman, Alexandra Nieters

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

Original language	English
Pages (from-to)	5751
Number of pages	7
Journal	Nature Communications [E]
Volume	6
DOIs	https://doi.org/10.1038/ncomms6751
Publication status	Published - 2015

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Vijai, J., Wang, Z., Berndt, S. I., Skibola, C. F., Slager, S. L., de Sanjose, S., Melbye, M., Glimelius, B., Bracci, P. M., Conde, L., Birmann, B. M., Wang, S. S., Brooks-Wilson, A. R., Lan, Q., de Bakker, P. I. W., Vermeulen, R. C. H., Portlock, C., Ansell, S. M., Link, B. K., ... Nieters, A. (2015). A genome-wide association study of marginal zone lymphoma shows association to the HLA region. Nature Communications [E], 6, 5751. https://doi.org/10.1038/ncomms6751

@article{a66bb052d0954852a82262cd01df9ba4,

title = "A genome-wide association study of marginal zone lymphoma shows association to the HLA region",

abstract = "Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.",

author = "Joseph Vijai and Zhaoming Wang and Berndt, {Sonja I} and Skibola, {Christine F} and Slager, {Susan L} and {de Sanjose}, Silvia and Mads Melbye and Bengt Glimelius and Bracci, {Paige M} and Lucia Conde and Birmann, {Brenda M} and Wang, {Sophia S} and Brooks-Wilson, {Angela R} and Qing Lan and {de Bakker}, {Paul I W} and Vermeulen, {Roel C H} and Carol Portlock and Ansell, {Stephen M} and Link, {Brian K} and Jacques Riby and North, {Kari E} and Jian Gu and Henrik Hjalgrim and Wendy Cozen and Nikolaus Becker and Teras, {Lauren R} and Spinelli, {John J} and Jenny Turner and Yawei Zhang and Purdue, {Mark P} and Giles, {Graham G} and Kelly, {Rachel S} and Anne Zeleniuch-Jacquotte and Ennas, {Maria Grazia} and Alain Monnereau and Bertrand, {Kimberly A} and Demetrius Albanes and Tracy Lightfoot and Meredith Yeager and Chung, {Charles C} and Laurie Burdett and Amy Hutchinson and Charles Lawrence and Rebecca Montalvan and Liming Liang and Jinyan Huang and Baoshan Ma and Villano, {Danylo J} and Ann Maria and Marina Corines and Tinu Thomas and Novak, {Anne J} and Ahmet Dogan and Mark Liebow and Thompson, {Carrie A} and Witzig, {Thomas E} and Habermann, {Thomas M} and Weiner, {George J} and Smith, {Martyn T} and Holly, {Elizabeth A} and Jackson, {Rebecca D} and Tinker, {Lesley F} and Yuanqing Ye and Hans-Olov Adami and Smedby, {Karin E} and {De Roos}, {Anneclaire J} and Patricia Hartge and Morton, {Lindsay M} and Severson, {Richard K} and Yolanda Benavente and Paolo Boffetta and Paul Brennan and Lenka Foretova and Marc Maynadie and James McKay and Anthony Staines and Diver, {W Ryan} and Vajdic, {Claire M} and Armstrong, {Bruce K} and Anne Kricker and Tongzhang Zheng and Holford, {Theodore R} and Gianluca Severi and Paolo Vineis and Ferri, {Giovanni M} and Rosalia Ricco and Lucia Miligi and Jacqueline Clavel and Edward Giovannucci and Peter Kraft and Jarmo Virtamo and Alex Smith and Eleanor Kane and Eve Roman and Chiu, {Brian C H} and Fraumeni, {Joseph F} and Xifeng Wu and Cerhan, {James R} and Kenneth Offit and Chanock, {Stephen J} and Nathaniel Rothman and Alexandra Nieters",

year = "2015",

doi = "10.1038/ncomms6751",

language = "English",

volume = "6",

pages = "5751",

journal = "Nature Communications [E]",

issn = "2041-1723",

publisher = "Nature Publishing Group",

}

Vijai, J, Wang, Z, Berndt, SI, Skibola, CF, Slager, SL, de Sanjose, S, Melbye, M, Glimelius, B, Bracci, PM, Conde, L, Birmann, BM, Wang, SS, Brooks-Wilson, AR, Lan, Q, de Bakker, PIW, Vermeulen, RCH, Portlock, C, Ansell, SM, Link, BK, Riby, J, North, KE, Gu, J, Hjalgrim, H, Cozen, W, Becker, N, Teras, LR, Spinelli, JJ, Turner, J, Zhang, Y, Purdue, MP, Giles, GG, Kelly, RS, Zeleniuch-Jacquotte, A, Ennas, MG, Monnereau, A, Bertrand, KA, Albanes, D, Lightfoot, T, Yeager, M, Chung, CC, Burdett, L, Hutchinson, A, Lawrence, C, Montalvan, R, Liang, L, Huang, J, Ma, B, Villano, DJ, Maria, A, Corines, M, Thomas, T, Novak, AJ, Dogan, A, Liebow, M, Thompson, CA, Witzig, TE, Habermann, TM, Weiner, GJ, Smith, MT, Holly, EA, Jackson, RD, Tinker, LF, Ye, Y, Adami, H-O, Smedby, KE, De Roos, AJ, Hartge, P, Morton, LM, Severson, RK, Benavente, Y, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, Diver, WR, Vajdic, CM, Armstrong, BK, Kricker, A, Zheng, T, Holford, TR, Severi, G, Vineis, P, Ferri, GM, Ricco, R, Miligi, L, Clavel, J, Giovannucci, E, Kraft, P, Virtamo, J, Smith, A, Kane, E, Roman, E, Chiu, BCH, Fraumeni, JF, Wu, X, Cerhan, JR, Offit, K, Chanock, SJ, Rothman, N & Nieters, A 2015, 'A genome-wide association study of marginal zone lymphoma shows association to the HLA region', Nature Communications [E], vol. 6, pp. 5751. https://doi.org/10.1038/ncomms6751

TY - JOUR

T1 - A genome-wide association study of marginal zone lymphoma shows association to the HLA region

AU - Vijai, Joseph

AU - Wang, Zhaoming

AU - Berndt, Sonja I

AU - Skibola, Christine F

AU - Slager, Susan L

AU - de Sanjose, Silvia

AU - Melbye, Mads

AU - Glimelius, Bengt

AU - Bracci, Paige M

AU - Conde, Lucia

AU - Birmann, Brenda M

AU - Wang, Sophia S

AU - Brooks-Wilson, Angela R

AU - Lan, Qing

AU - de Bakker, Paul I W

AU - Vermeulen, Roel C H

AU - Portlock, Carol

AU - Ansell, Stephen M

AU - Link, Brian K

AU - Riby, Jacques

AU - North, Kari E

AU - Gu, Jian

AU - Hjalgrim, Henrik

AU - Cozen, Wendy

AU - Becker, Nikolaus

AU - Teras, Lauren R

AU - Spinelli, John J

AU - Turner, Jenny

AU - Zhang, Yawei

AU - Purdue, Mark P

AU - Giles, Graham G

AU - Kelly, Rachel S

AU - Zeleniuch-Jacquotte, Anne

AU - Ennas, Maria Grazia

AU - Monnereau, Alain

AU - Bertrand, Kimberly A

AU - Albanes, Demetrius

AU - Lightfoot, Tracy

AU - Yeager, Meredith

AU - Chung, Charles C

AU - Burdett, Laurie

AU - Hutchinson, Amy

AU - Lawrence, Charles

AU - Montalvan, Rebecca

AU - Liang, Liming

AU - Huang, Jinyan

AU - Ma, Baoshan

AU - Villano, Danylo J

AU - Maria, Ann

AU - Corines, Marina

AU - Thomas, Tinu

AU - Novak, Anne J

AU - Dogan, Ahmet

AU - Liebow, Mark

AU - Thompson, Carrie A

AU - Witzig, Thomas E

AU - Habermann, Thomas M

AU - Weiner, George J

AU - Smith, Martyn T

AU - Holly, Elizabeth A

AU - Jackson, Rebecca D

AU - Tinker, Lesley F

AU - Ye, Yuanqing

AU - Adami, Hans-Olov

AU - Smedby, Karin E

AU - De Roos, Anneclaire J

AU - Hartge, Patricia

AU - Morton, Lindsay M

AU - Severson, Richard K

AU - Benavente, Yolanda

AU - Boffetta, Paolo

AU - Brennan, Paul

AU - Foretova, Lenka

AU - Maynadie, Marc

AU - McKay, James

AU - Staines, Anthony

AU - Diver, W Ryan

AU - Vajdic, Claire M

AU - Armstrong, Bruce K

AU - Kricker, Anne

AU - Zheng, Tongzhang

AU - Holford, Theodore R

AU - Severi, Gianluca

AU - Vineis, Paolo

AU - Ferri, Giovanni M

AU - Ricco, Rosalia

AU - Miligi, Lucia

AU - Clavel, Jacqueline

AU - Giovannucci, Edward

AU - Kraft, Peter

AU - Virtamo, Jarmo

AU - Smith, Alex

AU - Kane, Eleanor

AU - Roman, Eve

AU - Chiu, Brian C H

AU - Fraumeni, Joseph F

AU - Wu, Xifeng

AU - Cerhan, James R

AU - Offit, Kenneth

AU - Chanock, Stephen J

AU - Rothman, Nathaniel

AU - Nieters, Alexandra

PY - 2015

Y1 - 2015

N2 - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

AB - Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

U2 - 10.1038/ncomms6751

DO - 10.1038/ncomms6751

M3 - Article

C2 - 25569183

SN - 2041-1723

VL - 6

SP - 5751

JO - Nature Communications [E]

JF - Nature Communications [E]

ER -

A genome-wide association study of marginal zone lymphoma shows association to the HLA region

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