A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Victor Enciso-Mora; Peter Broderick; Yussanne Ma; Ruth F Jarrett; Henrik Hjalgrim; Kari Hemminki; Anke van den Berg; Bianca Olver; Amy Lloyd; Sara E Dobbins; Tracy Lightfoot; Flora E van Leeuwen; Asta Försti; Arjan Diepstra; Annegien Broeks; Jayaram Vijayakrishnan; Lesley Shield; Annette Lake; Dorothy Montgomery; Eve Roman; Andreas Engert; Elke Pogge von Strandmann; Katrin S Reiners; Ilja M Nolte; Karin E Smedby; Hans-Olov Adami; Nicola S Russell; Bengt Glimelius; Stephen Hamilton-Dutoit; Marieke de Bruin; Lars P Ryder; Daniel Molin; Karina Meden Sorensen; Ellen T Chang; Malcolm Taylor; Rosie Cooke; Robert Hofstra; Helga Westers; Tom van Wezel; Ronald van Eijk; Alan Ashworth; Klaus Rostgaard; Mads Melbye; Anthony J Swerdlow; Richard S Houlston

doi:10.1038/ng.696

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Victor Enciso-Mora, Peter Broderick, Yussanne Ma, Ruth F Jarrett, Henrik Hjalgrim, Kari Hemminki, Anke van den Berg, Bianca Olver, Amy Lloyd, Sara E Dobbins, Tracy Lightfoot, Flora E van Leeuwen, Asta Försti, Arjan Diepstra, Annegien Broeks, Jayaram Vijayakrishnan, Lesley Shield, Annette Lake, Dorothy Montgomery, Eve RomanAndreas Engert, Elke Pogge von Strandmann, Katrin S Reiners, Ilja M Nolte, Karin E Smedby, Hans-Olov Adami, Nicola S Russell, Bengt Glimelius, Stephen Hamilton-Dutoit, Marieke de Bruin, Lars P Ryder, Daniel Molin, Karina Meden Sorensen, Ellen T Chang, Malcolm Taylor, Rosie Cooke, Robert Hofstra, Helga Westers, Tom van Wezel, Ronald van Eijk, Alan Ashworth, Klaus Rostgaard, Mads Melbye, Anthony J Swerdlow, Richard S Houlston

Pharmacoepidemiology and Clinical Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.

Original language	English
Pages (from-to)	1126-30
Number of pages	5
Journal	Nature Genetics
Volume	42
Issue number	12
DOIs	https://doi.org/10.1038/ng.696
Publication status	Published - Dec 2010

Keywords

Adult
Chromosomes, Human
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 8
Female
GATA3 Transcription Factor
Genetic Loci
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Hodgkin Disease
Humans
Male
Polymorphism, Single Nucleotide
Proto-Oncogene Proteins c-rel
Recombination, Genetic

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10.1038/ng.696

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Enciso-Mora, V., Broderick, P., Ma, Y., Jarrett, R. F., Hjalgrim, H., Hemminki, K., van den Berg, A., Olver, B., Lloyd, A., Dobbins, S. E., Lightfoot, T., van Leeuwen, F. E., Försti, A., Diepstra, A., Broeks, A., Vijayakrishnan, J., Shield, L., Lake, A., Montgomery, D., ... Houlston, R. S. (2010). A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genetics, 42(12), 1126-30. https://doi.org/10.1038/ng.696

@article{831ff46ef7574c698024f5aebcbb53dc,

title = "A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)",

abstract = "To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.",

keywords = "Adult, Chromosomes, Human, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 2, Chromosomes, Human, Pair 8, Female, GATA3 Transcription Factor, Genetic Loci, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Hodgkin Disease, Humans, Male, Polymorphism, Single Nucleotide, Proto-Oncogene Proteins c-rel, Recombination, Genetic",

author = "Victor Enciso-Mora and Peter Broderick and Yussanne Ma and Jarrett, {Ruth F} and Henrik Hjalgrim and Kari Hemminki and {van den Berg}, Anke and Bianca Olver and Amy Lloyd and Dobbins, {Sara E} and Tracy Lightfoot and {van Leeuwen}, {Flora E} and Asta F{\"o}rsti and Arjan Diepstra and Annegien Broeks and Jayaram Vijayakrishnan and Lesley Shield and Annette Lake and Dorothy Montgomery and Eve Roman and Andreas Engert and {von Strandmann}, {Elke Pogge} and Reiners, {Katrin S} and Nolte, {Ilja M} and Smedby, {Karin E} and Hans-Olov Adami and Russell, {Nicola S} and Bengt Glimelius and Stephen Hamilton-Dutoit and {de Bruin}, Marieke and Ryder, {Lars P} and Daniel Molin and Sorensen, {Karina Meden} and Chang, {Ellen T} and Malcolm Taylor and Rosie Cooke and Robert Hofstra and Helga Westers and {van Wezel}, Tom and {van Eijk}, Ronald and Alan Ashworth and Klaus Rostgaard and Mads Melbye and Swerdlow, {Anthony J} and Houlston, {Richard S}",

year = "2010",

month = dec,

doi = "10.1038/ng.696",

language = "English",

volume = "42",

pages = "1126--30",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "12",

}

Enciso-Mora, V, Broderick, P, Ma, Y, Jarrett, RF, Hjalgrim, H, Hemminki, K, van den Berg, A, Olver, B, Lloyd, A, Dobbins, SE, Lightfoot, T, van Leeuwen, FE, Försti, A, Diepstra, A, Broeks, A, Vijayakrishnan, J, Shield, L, Lake, A, Montgomery, D, Roman, E, Engert, A, von Strandmann, EP, Reiners, KS, Nolte, IM, Smedby, KE, Adami, H-O, Russell, NS, Glimelius, B, Hamilton-Dutoit, S, de Bruin, M, Ryder, LP, Molin, D, Sorensen, KM, Chang, ET, Taylor, M, Cooke, R, Hofstra, R, Westers, H, van Wezel, T, van Eijk, R, Ashworth, A, Rostgaard, K, Melbye, M, Swerdlow, AJ & Houlston, RS 2010, 'A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)', Nature Genetics, vol. 42, no. 12, pp. 1126-30. https://doi.org/10.1038/ng.696

TY - JOUR

T1 - A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

AU - Enciso-Mora, Victor

AU - Broderick, Peter

AU - Ma, Yussanne

AU - Jarrett, Ruth F

AU - Hjalgrim, Henrik

AU - Hemminki, Kari

AU - van den Berg, Anke

AU - Olver, Bianca

AU - Lloyd, Amy

AU - Dobbins, Sara E

AU - Lightfoot, Tracy

AU - van Leeuwen, Flora E

AU - Försti, Asta

AU - Diepstra, Arjan

AU - Broeks, Annegien

AU - Vijayakrishnan, Jayaram

AU - Shield, Lesley

AU - Lake, Annette

AU - Montgomery, Dorothy

AU - Roman, Eve

AU - Engert, Andreas

AU - von Strandmann, Elke Pogge

AU - Reiners, Katrin S

AU - Nolte, Ilja M

AU - Smedby, Karin E

AU - Adami, Hans-Olov

AU - Russell, Nicola S

AU - Glimelius, Bengt

AU - Hamilton-Dutoit, Stephen

AU - de Bruin, Marieke

AU - Ryder, Lars P

AU - Molin, Daniel

AU - Sorensen, Karina Meden

AU - Chang, Ellen T

AU - Taylor, Malcolm

AU - Cooke, Rosie

AU - Hofstra, Robert

AU - Westers, Helga

AU - van Wezel, Tom

AU - van Eijk, Ronald

AU - Ashworth, Alan

AU - Rostgaard, Klaus

AU - Melbye, Mads

AU - Swerdlow, Anthony J

AU - Houlston, Richard S

PY - 2010/12

Y1 - 2010/12

N2 - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.

AB - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10(-8)). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10(-50)). These data provide new insight into the pathogenesis of cHL.

KW - Adult

KW - Chromosomes, Human

KW - Chromosomes, Human, Pair 10

KW - Chromosomes, Human, Pair 2

KW - Chromosomes, Human, Pair 8

KW - Female

KW - GATA3 Transcription Factor

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome, Human

KW - Genome-Wide Association Study

KW - Hodgkin Disease

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Proto-Oncogene Proteins c-rel

KW - Recombination, Genetic

U2 - 10.1038/ng.696

DO - 10.1038/ng.696

M3 - Article

C2 - 21037568

SN - 1061-4036

VL - 42

SP - 1126

EP - 1130

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Abstract

Keywords

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