A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging

M.M. van Schooneveld; D.P. Cormode; R. Koole; J.T. van Wijngaarden; C. Calcagno; T. Skajaa; J. Hilhorst; D.C. 't Hart; Z.A. Fayad; W.J.M. Mulder; A. Meijerink

doi:10.1002/cmmi.376

A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging

M.M. van Schooneveld
, D.P. Cormode
, R. Koole
, J.T. van Wijngaarden
, C. Calcagno
, T. Skajaa
, J. Hilhorst
, D.C. 't Hart
, Z.A. Fayad
, W.J.M. Mulder
, A. Meijerink

extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging

Original language	English
Pages (from-to)	231-236
Number of pages	6
Journal	Contrast Media & molecular imaging
Volume	5
Issue number	4
DOIs	https://doi.org/10.1002/cmmi.376
Publication status	Published - 2010

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Afluorescentparamagnetic SChooneveld 2010
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van Schooneveld, M. M., Cormode, D. P., Koole, R., van Wijngaarden, J. T., Calcagno, C., Skajaa, T., Hilhorst, J., 't Hart, D. C., Fayad, Z. A., Mulder, W. J. M., & Meijerink, A. (2010). A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging. Contrast Media & molecular imaging, 5(4), 231-236. https://doi.org/10.1002/cmmi.376

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title = "A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging",

abstract = "An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging",

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doi = "10.1002/cmmi.376",

language = "English",

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AU - van Schooneveld, M.M.

AU - Cormode, D.P.

AU - Koole, R.

AU - van Wijngaarden, J.T.

AU - Calcagno, C.

AU - Skajaa, T.

AU - Hilhorst, J.

AU - 't Hart, D.C.

AU - Fayad, Z.A.

AU - Mulder, W.J.M.

AU - Meijerink, A.

PY - 2010

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N2 - An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging

AB - An important challenge in medical diagnostics is to design all-in-one contrast agents that can be detected with multiple techniques such as magnetic resonance imaging (MRI), X-ray computed tomography (CT), positron emission tomography (PET), single photon emission tomography (SPECT) or fluorescence imaging (FI). Although many dual labeled agents have been proposed, mainly for combined MRI/FI, constructs for three imaging modalities are scarce. Here gold/silica nanoparticles with a poly(ethylene glycol), paramagnetic and fluorescent lipid coating were synthesized, characterized and applied as trimodal contrast agents to allow for nanoparticle-enhanced imaging of macrophage cells in vitro via MRI, CT and FI, and mice livers in vivo via MRI and CT. This agent can be a useful tool in a multitude of applications, including cell tracking and target-specific molecular imaging, and is a step in the direction of truly multi-modal imaging

U2 - 10.1002/cmmi.376

DO - 10.1002/cmmi.376

M3 - Article

SN - 1555-4309

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EP - 236

JO - Contrast Media & molecular imaging

JF - Contrast Media & molecular imaging

IS - 4

ER -

A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging

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