Abstract
Background: In the last decades, 3D-printing has been investigated and used intensively in the field of tissue engineering, automotive and aerospace. With the first FDA approved printed medicinal product in 2015, the research on 3D-printing for pharmaceutical application has attracted the attention of pharmaceutical scientists. Due to its potential of fabricating complex structures and geometrics, it is a highly promising technology for manufacturing individualized dosage forms. In addition, it enables the fabrication of dosage forms with tailored drug release profiles. Objective: The aim of this review article is to give a comprehensive overview of the used 3D-printing techniques for pharmaceutical applications, including information about the required material, advantages and disadvantages of the respective technique. Methods: For the literature research, relevant keywords were identified and the literature was then thoroughly researched. Conclusion: The current status of 3D-printing as a manufacturing process for pharmaceutical dosage forms was highlighted in this review article. Moreover, this article presents a critical evaluation of 3D-printing to control the dose and drug release of printed dosage forms.
| Original language | English |
|---|---|
| Pages (from-to) | 4957-4978 |
| Number of pages | 22 |
| Journal | Current Pharmaceutical Design |
| Volume | 24 |
| Issue number | 42 |
| DOIs | |
| Publication status | Published - 2018 |
Bibliographical note
Publisher Copyright:© 2018 Bentham Science Publishers.
Keywords
- 3D-printing
- Drop-on-solid
- Drug release control
- Fused filament fabrication
- Individualized medicine
- Pressure-assisted microsyringe
- Selective laser sintering
- Stereolithography