A Comparison of Within-Subjects and Between-Subjects Designs in Studies with Discrete-Time Survival Outcomes

M. Safarkhani, M. Moerbeek

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Crossover designs are well-known to have major advantages when comparing the effects of various non-curative treatments. We compare efficiencies of several crossover designs along with the Balaam’s design with that of a parallel group design pertaining to longitudinal studies where event time can only be measured in discrete time intervals. With equally sized sequences, the parallel group design results in the greater efficiency if the number of time periods is small. However, the crossover and Balaam’s designs tend to be more efficient as the study duration increases. The degree to which these designs add efficiency depends on the baseline hazard function and effect size. Additionally, we incorporate different cost considerations at the subject level when comparing the designs to determine the most cost-efficient design. Researchers
might consider the crossover or Balaam’s design more efficient if the duration of the study is long enough, especially if the costs of applying the baseline treatment are higher.
Original languageEnglish
Pages (from-to)305-322
Number of pages18
JournalOpen Journal of Statistics
Volume7
Issue number7
DOIs
Publication statusPublished - 2017

Keywords

  • Balaam's design
  • Crossover design
  • Cost-efficiency
  • Discrete-time survival endpoint
  • Efficiency measure
  • Parallel group design

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