A case of ALS with posterior cortical atrophy

Tanja C.W. Nijboer; Bram Nitert; Henk Jan Westeneng; Leonard H. Van Den Berg; Michael A. van Es

doi:10.1080/21678421.2019.1632348

A case of ALS with posterior cortical atrophy

Tanja C.W. Nijboer
, Bram Nitert
, Henk Jan Westeneng
, Leonard H. Van Den Berg
, Michael A. van Es^*

^*Corresponding author for this work

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University
Research Centre of Excellence in Rehabilitation Medicine Utrecht Brain Center Rudolf Magnus and De Hoogstraat Rehabilitation.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Here, we provide a case-report of an amyotrophic lateral sclerosis (ALS) patient with cognitive deficits best defined as posterior cortical atrophy (PCA). This is an unusual finding as ALS forms a spectrum with frontotemporal dementia (FTD), whereas PCA is predominantly associated with Alzheimer’s disease pathology. We hypothesize on whether ALS with PCA might be an under recognized phenotype considering multiple imaging studies in ALS have also reported (asymptomatic) parietal atrophy.

Original language	English
Pages (from-to)	506-510
Number of pages	5
Journal	Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume	20
Issue number	7-8
DOIs	https://doi.org/10.1080/21678421.2019.1632348
Publication status	Published - 2 Oct 2019

Funding

MAvE received grants from the Netherlands Organization for Health Research and Development (Veni scheme), Joint Program Neurodegeneration (JPND), The Thierry Latran foundation and the Netherlands ALS foundation (Stichting ALS Nederland). He received travel grants from Shire (formerly Baxalta) and has consulted for Biogen.

Keywords

Amyotrophic lateral sclerosis
MND-FTD continuum
posterior cortical atrophy

Access to Document

10.1080/21678421.2019.1632348

nijboerFinal published version, 931 KB

Cite this

@article{b44b8d77829c4a699676fed349831dc8,

title = "A case of ALS with posterior cortical atrophy",

abstract = "Here, we provide a case-report of an amyotrophic lateral sclerosis (ALS) patient with cognitive deficits best defined as posterior cortical atrophy (PCA). This is an unusual finding as ALS forms a spectrum with frontotemporal dementia (FTD), whereas PCA is predominantly associated with Alzheimer{\textquoteright}s disease pathology. We hypothesize on whether ALS with PCA might be an under recognized phenotype considering multiple imaging studies in ALS have also reported (asymptomatic) parietal atrophy.",

keywords = "Amyotrophic lateral sclerosis, MND-FTD continuum, posterior cortical atrophy",

author = "Nijboer, \{Tanja C.W.\} and Bram Nitert and Westeneng, \{Henk Jan\} and \{Van Den Berg\}, \{Leonard H.\} and \{van Es\}, \{Michael A.\}",

year = "2019",

month = oct,

day = "2",

doi = "10.1080/21678421.2019.1632348",

language = "English",

volume = "20",

pages = "506--510",

journal = "Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration",

issn = "2167-8421",

publisher = "Taylor and Francis",

number = "7-8",

}

TY - JOUR

T1 - A case of ALS with posterior cortical atrophy

AU - Nijboer, Tanja C.W.

AU - Nitert, Bram

AU - Westeneng, Henk Jan

AU - Van Den Berg, Leonard H.

AU - van Es, Michael A.

PY - 2019/10/2

Y1 - 2019/10/2

N2 - Here, we provide a case-report of an amyotrophic lateral sclerosis (ALS) patient with cognitive deficits best defined as posterior cortical atrophy (PCA). This is an unusual finding as ALS forms a spectrum with frontotemporal dementia (FTD), whereas PCA is predominantly associated with Alzheimer’s disease pathology. We hypothesize on whether ALS with PCA might be an under recognized phenotype considering multiple imaging studies in ALS have also reported (asymptomatic) parietal atrophy.

AB - Here, we provide a case-report of an amyotrophic lateral sclerosis (ALS) patient with cognitive deficits best defined as posterior cortical atrophy (PCA). This is an unusual finding as ALS forms a spectrum with frontotemporal dementia (FTD), whereas PCA is predominantly associated with Alzheimer’s disease pathology. We hypothesize on whether ALS with PCA might be an under recognized phenotype considering multiple imaging studies in ALS have also reported (asymptomatic) parietal atrophy.

KW - Amyotrophic lateral sclerosis

KW - MND-FTD continuum

KW - posterior cortical atrophy

UR - https://www.scopus.com/pages/publications/85068688613

U2 - 10.1080/21678421.2019.1632348

DO - 10.1080/21678421.2019.1632348

M3 - Article

C2 - 31284766

AN - SCOPUS:85068688613

SN - 2167-8421

VL - 20

SP - 506

EP - 510

JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

IS - 7-8

ER -

A case of ALS with posterior cortical atrophy

Abstract

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this