5.14 Biofabrication in tissue engineering

T. Woodfield; K. Lim; P. Morouço; R. Levato; J. Malda; F. Melchels

doi:10.1016/B978-0-12-803581-8.10221-8

5.14 Biofabrication in tissue engineering

T. Woodfield, K. Lim, P. Morouço, R. Levato, J. Malda, F. Melchels

Equine Musculoskeletal Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

Biofabrication techniques offer the potential to produce living three-dimensional (3D) tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these advanced Biofabrication techniques, constructs exhibiting spatial variation of cells, cellular building blocks, growth factors, and mechanical properties along multiple axes with high geometric complexity can be obtained. The level of control offered by these technologies to develop complex biofabricated tissues will allow tissue engineers to better study factors that modulate tissue formation and function, and provide a valuable tool to study graft performance as well as for high throughput screening of drug candidates in biofabricated tissue organoid models.

Original language	English
Title of host publication	Comprehensive Biomaterials II
Publisher	Elsevier
Pages	236-266
Number of pages	31
ISBN (Electronic)	9780081006924
ISBN (Print)	9780081006917
DOIs	https://doi.org/10.1016/B978-0-12-803581-8.10221-8
Publication status	Published - 1 Jan 2017

Keywords

3D bioassembly
3D bioprinting
3D organoids
3D plotting
Biofabrication
Bioink
Bioresin
Computer aided design
Hierarchical tissues
High throughput screening
Hybrid construct fabrication
Hydrogel
Nutrient diffusion
Organotypic in vitro models
Substrate patterning
Tissue engineering
Vascularization

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10.1016/B978-0-12-803581-8.10221-8

Cite this

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abstract = "Biofabrication techniques offer the potential to produce living three-dimensional (3D) tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these advanced Biofabrication techniques, constructs exhibiting spatial variation of cells, cellular building blocks, growth factors, and mechanical properties along multiple axes with high geometric complexity can be obtained. The level of control offered by these technologies to develop complex biofabricated tissues will allow tissue engineers to better study factors that modulate tissue formation and function, and provide a valuable tool to study graft performance as well as for high throughput screening of drug candidates in biofabricated tissue organoid models.",

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AU - Woodfield, T.

AU - Lim, K.

AU - Morouço, P.

AU - Levato, R.

AU - Malda, J.

AU - Melchels, F.

PY - 2017/1/1

Y1 - 2017/1/1

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AB - Biofabrication techniques offer the potential to produce living three-dimensional (3D) tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these advanced Biofabrication techniques, constructs exhibiting spatial variation of cells, cellular building blocks, growth factors, and mechanical properties along multiple axes with high geometric complexity can be obtained. The level of control offered by these technologies to develop complex biofabricated tissues will allow tissue engineers to better study factors that modulate tissue formation and function, and provide a valuable tool to study graft performance as well as for high throughput screening of drug candidates in biofabricated tissue organoid models.

KW - 3D bioassembly

KW - 3D bioprinting

KW - 3D organoids

KW - 3D plotting

KW - Biofabrication

KW - Bioink

KW - Bioresin

KW - Computer aided design

KW - Hierarchical tissues

KW - High throughput screening

KW - Hybrid construct fabrication

KW - Hydrogel

KW - Nutrient diffusion

KW - Organotypic in vitro models

KW - Substrate patterning

KW - Tissue engineering

KW - Vascularization

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SN - 9780081006917

SP - 236

EP - 266

BT - Comprehensive Biomaterials II

PB - Elsevier

ER -

5.14 Biofabrication in tissue engineering

Abstract

Keywords

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