2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Marc P Baggelaar; Mauro Maccarrone; Mario van der Stelt

doi:10.1016/j.plipres.2018.05.002

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Marc P Baggelaar
, Mauro Maccarrone
, Mario van der Stelt

Leiden University
Campus Bio-Medico University of Rome
Leiden University

Research output: Contribution to journal › Review article › peer-review

Abstract

2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.

Original language	English
Pages (from-to)	1-17
Number of pages	17
Journal	Progress in Lipid Research
Volume	71
DOIs	https://doi.org/10.1016/j.plipres.2018.05.002
Publication status	Published - Jul 2018
Externally published	Yes

Bibliographical note

Keywords

Animals
Arachidonic Acids/chemical synthesis
Biosynthetic Pathways
Brain/metabolism
Endocannabinoids/chemical synthesis
Glycerides/chemical synthesis
Humans
Lipid Metabolism
Models, Chemical
Molecular Structure
Receptor, Cannabinoid, CB1/metabolism
Signal Transduction

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10.1016/j.plipres.2018.05.002Licence: CC BY-NC-ND

Cite this

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title = "2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain",

abstract = "2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.",

keywords = "Animals, Arachidonic Acids/chemical synthesis, Biosynthetic Pathways, Brain/metabolism, Endocannabinoids/chemical synthesis, Glycerides/chemical synthesis, Humans, Lipid Metabolism, Models, Chemical, Molecular Structure, Receptor, Cannabinoid, CB1/metabolism, Signal Transduction",

author = "Baggelaar, \{Marc P\} and Mauro Maccarrone and \{van der Stelt\}, Mario",

year = "2018",

month = jul,

doi = "10.1016/j.plipres.2018.05.002",

language = "English",

volume = "71",

pages = "1--17",

journal = "Progress in Lipid Research",

issn = "0163-7827",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - 2-Arachidonoylglycerol

T2 - A signaling lipid with manifold actions in the brain

AU - Baggelaar, Marc P

AU - Maccarrone, Mauro

AU - van der Stelt, Mario

PY - 2018/7

Y1 - 2018/7

N2 - 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.

AB - 2-Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the cannabinoid CB1 receptor. It is involved in a wide array of (patho)physiological functions, such as emotion, cognition, energy balance, pain sensation and neuroinflammation. In this review, we describe the biosynthetic and metabolic pathways of 2-AG and how chemical and genetic perturbation of these pathways has led to insight in the biological role of this signaling lipid. Finally, we discuss the potential therapeutic benefits of modulating 2-AG levels in the brain.

KW - Animals

KW - Arachidonic Acids/chemical synthesis

KW - Biosynthetic Pathways

KW - Brain/metabolism

KW - Endocannabinoids/chemical synthesis

KW - Glycerides/chemical synthesis

KW - Humans

KW - Lipid Metabolism

KW - Models, Chemical

KW - Molecular Structure

KW - Receptor, Cannabinoid, CB1/metabolism

KW - Signal Transduction

U2 - 10.1016/j.plipres.2018.05.002

DO - 10.1016/j.plipres.2018.05.002

M3 - Review article

C2 - 29751000

SN - 0163-7827

VL - 71

SP - 1

EP - 17

JO - Progress in Lipid Research

JF - Progress in Lipid Research

ER -

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Abstract

Bibliographical note

Keywords

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