H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis

A. Neumoin; A. Leonchiks; P. Petit; L. Vuillard; M. Pizza; M. Soriani; R. Boelens; A. M. J. J. Bonvin

doi:10.1007/s12104-010-9285-y

H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis

A. Neumoin, A. Leonchiks, P. Petit, L. Vuillard, M. Pizza, M. Soriani, R. Boelens, A. M. J. J. Bonvin

Novartis

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H-1, C-13 and N-15 resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.

Original language	English
Pages (from-to)	135-138
Number of pages	4
Journal	Biomolecular NMR Assignments
Volume	5
Issue number	2
DOIs	https://doi.org/10.1007/s12104-010-9285-y
Publication status	Published - Oct 2011

Keywords

Antigen
Liporotein
Meningitis
Nmr
Pathogenic bacteria

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title = "H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis",

abstract = "GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H-1, C-13 and N-15 resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.",

keywords = "Antigen, Liporotein, Meningitis, Nmr, Pathogenic bacteria",

author = "A. Neumoin and A. Leonchiks and P. Petit and L. Vuillard and M. Pizza and M. Soriani and R. Boelens and Bonvin, \{A. M. J. J.\}",

year = "2011",

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doi = "10.1007/s12104-010-9285-y",

language = "English",

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TY - JOUR

T1 - H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis

AU - Neumoin, A.

AU - Leonchiks, A.

AU - Petit, P.

AU - Vuillard, L.

AU - Pizza, M.

AU - Soriani, M.

AU - Boelens, R.

AU - Bonvin, A. M. J. J.

PY - 2011/10

Y1 - 2011/10

N2 - GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H-1, C-13 and N-15 resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.

AB - GNA1946 (Genome-derived Neisseria Antigen 1946) is a highly conserved exposed outer membrane lipoprotein from Neisseria meningitidis bacteria of 287 amino acid length (31 kDa). Although the structure of NMB1946 has been solved recently by X-Ray crystallography, understanding the behaviour of GNA1946 in aqueuos solution is highly relevant for the discovery of the antigenic determinants of the protein that will possibly lead to a more efficient vaccine development against virulent serogroup B strain of N.meningitidis. Here we report almost complete H-1, C-13 and N-15 resonance assignments of GNA1946 (residues 10-287) in aqueous buffer solution.

KW - Antigen

KW - Liporotein

KW - Meningitis

KW - Nmr

KW - Pathogenic bacteria

U2 - 10.1007/s12104-010-9285-y

DO - 10.1007/s12104-010-9285-y

M3 - Article

C2 - 21188561

SN - 1874-270X

VL - 5

SP - 135

EP - 138

JO - Biomolecular NMR Assignments

JF - Biomolecular NMR Assignments

IS - 2

ER -

H-1, C-13 and N-15 assignment of the GNA1946 outer membrane lipoprotein from Neisseria meningitidis

Abstract

Keywords

UN SDGs

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