17q21 variants modify the association between early respiratory infections and asthma.

L.A. Smit; E. Bouzigon; V. Pin; V. Siroux; F. Monier; H. Aschard; J. Bousquet; F. Gormand; J. Just; N. le Moual; R. Nadif; P. Scheinmann; D. Vervloet; M. Lathrop; F. Demenais; F. Kauffmann

doi:10.1183/09031936.00154509

17q21 variants modify the association between early respiratory infections and asthma.

L.A. Smit, E. Bouzigon, V. Pin, V. Siroux, F. Monier, H. Aschard, J. Bousquet, F. Gormand, J. Just, N. le Moual, R. Nadif, P. Scheinmann, D. Vervloet, M. Lathrop, F. Demenais, F. Kauffmann

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset

Original language	Undefined/Unknown
Pages (from-to)	57-64
Number of pages	8
Journal	European Respiratory Journal
Volume	36
Issue number	1
DOIs	https://doi.org/10.1183/09031936.00154509
Publication status	Published - 2010

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Smit-Eur Respir J 2010 36 57-64
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Smit, L. A., Bouzigon, E., Pin, V., Siroux, V., Monier, F., Aschard, H., Bousquet, J., Gormand, F., Just, J., le Moual, N., Nadif, R., Scheinmann, P., Vervloet, D., Lathrop, M., Demenais, F., & Kauffmann, F. (2010). 17q21 variants modify the association between early respiratory infections and asthma. European Respiratory Journal, 36(1), 57-64. https://doi.org/10.1183/09031936.00154509

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abstract = "Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset",

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Smit, LA, Bouzigon, E, Pin, V, Siroux, V, Monier, F, Aschard, H, Bousquet, J, Gormand, F, Just, J, le Moual, N, Nadif, R, Scheinmann, P, Vervloet, D, Lathrop, M, Demenais, F & Kauffmann, F 2010, '17q21 variants modify the association between early respiratory infections and asthma.', European Respiratory Journal, vol. 36, no. 1, pp. 57-64. https://doi.org/10.1183/09031936.00154509

TY - JOUR

T1 - 17q21 variants modify the association between early respiratory infections and asthma.

AU - Smit, L.A.

AU - Bouzigon, E.

AU - Pin, V.

AU - Siroux, V.

AU - Monier, F.

AU - Aschard, H.

AU - Bousquet, J.

AU - Gormand, F.

AU - Just, J.

AU - le Moual, N.

AU - Nadif, R.

AU - Scheinmann, P.

AU - Vervloet, D.

AU - Lathrop, M.

AU - Demenais, F.

AU - Kauffmann, F.

PY - 2010

Y1 - 2010

N2 - Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset

AB - Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset

U2 - 10.1183/09031936.00154509

DO - 10.1183/09031936.00154509

M3 - Article

SN - 0903-1936

VL - 36

SP - 57

EP - 64

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 1

ER -