13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4in vivo in rabbit skin

T.L. Buckley; M.J. Van De Velde; P.A.J. Henricks; F. Engels; F.P. Nijkamp

doi:10.1016/0014-2999(92)90195-A

13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4in vivo in rabbit skin

T.L. Buckley, M.J. Van De Velde, P.A.J. Henricks, F. Engels, F.P. Nijkamp

Pharmacology

External unknown

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10-11- 10-9mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4(LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10-11mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4that could have important implications in the pathogenesis of inflammation.

Original language	English
Pages (from-to)	369-372
Number of pages	4
Journal	European Journal of Pharmacology
Volume	218
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(92)90195-A
Publication status	Published - 26 Jan 1992

Keywords

13-HODE (13-hydroxyoctadecadienoic acid)
leukotriene B4
oedema formation
skin (rabbit)
13 hydroxyoctadecadienoic acid
antiinflammatory agent
bradykinin
calcitonin gene related peptide
histamine
unclassified drug
animal experiment
animal model
article
controlled study
drug antagonism
edema
inflammation
intradermal drug administration
nonhuman
priority journal
rabbit
skin

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10.1016/0014-2999(92)90195-A

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@article{0cbeacdf096544d8bbc30a2d360b70f1,

title = "13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4in vivo in rabbit skin",

abstract = "Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10-11- 10-9mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4(LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10-11mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4that could have important implications in the pathogenesis of inflammation.",

keywords = "13-HODE (13-hydroxyoctadecadienoic acid), leukotriene B4, oedema formation, skin (rabbit), 13 hydroxyoctadecadienoic acid, antiinflammatory agent, bradykinin, calcitonin gene related peptide, histamine, unclassified drug, animal experiment, animal model, article, controlled study, drug antagonism, edema, inflammation, intradermal drug administration, nonhuman, priority journal, rabbit, skin",

author = "T.L. Buckley and {Van De Velde}, M.J. and P.A.J. Henricks and F. Engels and F.P. Nijkamp",

year = "1992",

month = jan,

day = "26",

doi = "10.1016/0014-2999(92)90195-A",

language = "English",

volume = "218",

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journal = "European Journal of Pharmacology",

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TY - JOUR

T1 - 13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4in vivo in rabbit skin

AU - Buckley, T.L.

AU - Van De Velde, M.J.

AU - Henricks, P.A.J.

AU - Engels, F.

AU - Nijkamp, F.P.

PY - 1992/1/26

Y1 - 1992/1/26

N2 - Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10-11- 10-9mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4(LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10-11mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4that could have important implications in the pathogenesis of inflammation.

AB - Intradermal 13-hydroxyoctadecadienoic acid (13-HODE; 10-11- 10-9mol/site) inhibited oedema formation induced by the neutrophil-dependent mediator leukotriene B4(LTB4) in the presence of calcitonin gene-related peptide (CGRP; 10-11mol/site) in rabbit skin. In contrast, the responses to the direct acting mediators bradykinin and histamine were unaffected by 13-HODE. 13-HODE failed to induce oedema formation in rabbit skin when injected alone or in the presence of the potent vasodilator CGRP. These results present a novel interaction between 13-HODE and LTB4that could have important implications in the pathogenesis of inflammation.

KW - 13-HODE (13-hydroxyoctadecadienoic acid)

KW - leukotriene B4

KW - oedema formation

KW - skin (rabbit)

KW - 13 hydroxyoctadecadienoic acid

KW - antiinflammatory agent

KW - bradykinin

KW - calcitonin gene related peptide

KW - histamine

KW - unclassified drug

KW - animal experiment

KW - animal model

KW - article

KW - controlled study

KW - drug antagonism

KW - edema

KW - inflammation

KW - intradermal drug administration

KW - nonhuman

KW - priority journal

KW - rabbit

KW - skin

U2 - 10.1016/0014-2999(92)90195-A

DO - 10.1016/0014-2999(92)90195-A

M3 - Article

SN - 0014-2999

VL - 218

SP - 369

EP - 372

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

13-Hydroxyoctadecadienoic acid attenuates oedema formation induced by leukotriene B4in vivo in rabbit skin

Abstract

Keywords

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