Betty van Esch

2025

Bacterial diversity, bioactive peptides, and enhanced immunomodulatory effects in raw milk kefir made with defined starter cultures versus backslopping

Baars, T., van Esch, B., Diks, M., van Ooijen, L., Zhang, Z., Dekker, P., Boeren, S., Garssen, J., Hettinga, K. & Kort, R., May 2025, In: International Dairy Journal. 164, 9 p., 106202.

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2024

Dietary composition of adult eosinophilic esophagitis patients is related to disease severity

Eussen, S. R. B. M., Wielders, S., de Rooij, W. E., Van Ampting, M. T. J., Van Esch, B. C. A. M., de Vries, J. H. M., Bredenoord, A. J. & Vlieg-Boerstra, B., Mar 2024, In: Immunity, inflammation and disease. 12, 3, p. 1-11 11 p., e1206.

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Metabolic pathways in immune senescence and inflammaging: Novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology

Roth-Walter, F., Adcock, I. M., Benito-Villalvilla, C., Bianchini, R., Bjermer, L., Caramori, G., Cari, L., Chung, K. F., Diamant, Z., Eguiluz-Gracia, I., Knol, E. F., Jesenak, M., Levi-Schaffer, F., Nocentini, G., O'Mahony, L., Palomares, O., Redegeld, F., Sokolowska, M., Van Esch, B. C. A. M. & Stellato, C., May 2024, In: Allergy: European Journal of Allergy and Clinical Immunology. 79, 5, p. 1089-1122 34 p.

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Transcriptomic profiling of the acute mucosal response to local food injections in adults with eosinophilic esophagitis

Kleuskens, M. T. A., Haasnoot, M. L., Garssen, J., Bredenoord, A. J., van Esch, B. C. A. M. & Redegeld, F. A., Mar 2024, In: Journal of Allergy and Clinical Immunology. 153, 3, p. 780-792 13 p.

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2023

Mast cells disrupt the function of the esophageal epithelial barrier

Kleuskens, M. T. A., Bek, M. K., Al Halabi, Y., Blokhuis, B. R. J., Diks, M. A. P., Haasnoot, M. L., Garssen, J., Bredenoord, A. J., van Esch, B. C. A. M. & Redegeld, F. A., Oct 2023, In: Mucosal Immunology. 16, 5, p. 567-577 11 p.

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Raw milk kefir: microbiota, bioactive peptides, and immune modulation

Baars, T., van Esch, B., van Ooijen, L., Zhang, Z., Dekker, P., Boeren, S., Diks, M., Garssen, J., Hettinga, K. & Kort, R., 24 Jan 2023, In: Food and Function. 14, 3, p. 1648-1661 14 p.

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2022

Butyrate and propionate restore interleukin 13-compromised esophageal epithelial barrier function

Kleuskens, M. T. A., Haasnoot, M. L., Herpers, B. M., van Ampting, M. T. J., Bredenoord, A. J., Garssen, J., Redegeld, F. A. & van Esch, B. C. A. M., May 2022, In: Allergy. 77, 5, p. 1510-1521 12 p.

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2021

Butyrate and propionate restore the cytokine and house dust mite compromised barrier function of human bronchial airway epithelial cells

Richards, L. B., Li, M., Folkerts, G., Henricks, P. A. J., Garssen, J. & van Esch, B. C. A. M., 2021, In: International Journal of Molecular Sciences. 22, 1, p. 1-16 16 p., 65.

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IL-33 Is Involved in the Anti-Inflammatory Effects of Butyrate and Propionate on TNFα-Activated Endothelial Cells

Li, M., van Esch, B. C. A. M., Henricks, P. A. J., Garssen, J. & Folkerts, G., 1 Mar 2021, In: International Journal of Molecular Sciences. 22, 5, p. 1-15 15 p., 2447.

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Immune modulation via T regulatory cell enhancement: disease-modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases - An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)

Roth-Walter, F., Adcock, I. M., Benito-Villalvilla, C., Bianchini, R., Bjermer, L., Boyman, O., Caramori, G., Cari, L., Chung, K. F., Diamant, Z., Eguiluz-Gracia, I., Knol, E. F., Kolios, A., Levi-Schaffer, F., Nocentini, G., Palomares, O., Redegeld, F., Van Esch, B. & Stellato, C., Jan 2021, In: Allergy. 76, 1, p. 90-113 24 p.

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Raw Milk-Induced Protection against Food Allergic Symptoms in Mice Is Accompanied by Shifts in Microbial Community Structure

Abbring, S., Engen, P. A., Naqib, A., Green, S. J., Garssen, J., Keshavarzian, A. & van Esch, B. C. A. M., 26 Mar 2021, In: International Journal of Molecular Sciences. 22, 7, p. 1-17 3417.

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2020

Altered microbial community structure and metabolism in cow's milk allergic mice treated with oral immunotherapy and fructo-oligosaccharides

Vonk, M. M., Engen, P. A., Naqib, A., Green, S. J., Keshavarzian, A., Blokhuis, B. R. J., Garssen, J., Knippels, L. M. J. & van Esch, B. C. A. M., 19 Feb 2020, In: Beneficial microbes. 11, 1, p. 19-32 14 p.

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A multi-center assessment to compare residual allergenicity of partial hydrolyzed whey proteins in a murine model for cow’s milk allergy – Comparison to the single parameter guinea pig model

van Esch, B. C. A. M., van Bilsen, J. H. M., Gros- van Hest, M., Kleinjans, L., Belzer, C., Jeurink, P. V., Garssen, J., Smit, J. J., Pieters, R. H. H. & Knippels, L. M. J., 15 Oct 2020, In: Toxicology Letters. 333, p. 312-321

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Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy

Alashkar Alhamwe, B., Meulenbroek, L. A. P. M., Veening-Griffioen, D. H., Wehkamp, T. M. D., Alhamdan, F., Miethe, S., Harb, H., Hogenkamp, A., Knippels, L. M. J., Pogge von Strandmann, E., Renz, H., Garssen, J., van Esch, B. C. A. M., Garn, H., Potaczek, D. P. & Tiemessen, M. M., 19 Oct 2020, In: Nutrients. 12, 10, 17 p., 3193.

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Direct Inhibition of the Allergic Effector Response by Raw Cow's Milk-An Extensive In Vitro Assessment

Abbring, S., Blokhuis, B. R. J., Miltenburg, J. L., Olmedo, K. G. J. R., Garssen, J., Redegeld, F. A. & Esch, B. C. A. M. V., 19 May 2020, In: Cells. 9, 5, 14 p., 1258.

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Loss of allergy-protective capacity of raw cow's milk after heat treatment coincides with loss of immunologically active whey proteins

Abbring, S., Xiong, L., Diks, M. A. P., Baars, T., Garssen, J., Hettinga, K. & van Esch, B. C. A. M., 24 Jun 2020, In: Food & function. 11, 6, p. 4982-4993 12 p.

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2019

A network-based approach for identifying suitable biomarkers for oral immunotherapy of food allergy

Van Bilsen, J. H. M., Verschuren, L., Wagenaar, L., Vonk, M. M., Van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Smit, J. J., Pieters, R. H. H. & Van Den Broek, T. J., 23 Apr 2019, In: BMC Bioinformatics. 20, 1, 206.

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Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice

Vonk, M. M., Blokhuis, B. R. J., Diks, M. A. P., Wagenaar, L., Smit, J. J., Pieters, R. H. H., Garssen, J., Knippels, L. M. J. & van Esch, B. C. A. M., 16 Jan 2019, In: Mediators of Inflammation. 2019, 12 p., 9062537.

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Comparing biologicals and small molecule drug therapies for chronic respiratory diseases

Roth-Walter, F., Adcock, I. M., Benito-Villalvilla, C., Bianchini, R., Bjermer, L., Caramori, G., Cari, L., Chung, K. F., Diamant, Z., Eguiluz-Gracia, I., Knol, E., Kolios, A., Levi-Schaffer, F., Nocentini, G., Palomares, O., Puzzovio, P. G., Redegeld, F., Van Esch, B. & Stellato, C., Mar 2019, In: Allergy. 74, 3, p. 432-448 17 p.

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Milk processing increases the allergenicity of cow's milk-Preclinical evidence supported by a human proof-of-concept provocation pilot

Abbring, S., Kusche, D., Roos, T. C., Diks, M. A. P., Hols, G., Garssen, J., Baars, T. & van Esch, B. C. A. M., Jul 2019, In: Clinical and Experimental Allergy. 49, 7, p. 1013-1025 13 p.

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Non-digestible oligosaccharides scFOS/lcFOS facilitate safe subcutaneous immunotherapy for peanut allergy

Wagenaar, L., Van Roest, M., Kruijssen, L. J. W., Simons, P. J., Boon, L., Vonk, M. M., Van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Pieters, R. H. H. & Smit, J. J., 4 Apr 2019, In: Clinical and Molecular Allergy. 17, 1, 7.

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Raw cow's milk consumption and allergic diseases: The potential role of bioactive whey proteins

Abbring, S., Hols, G., Garssen, J. & van Esch, B. C. A. M., 15 Jan 2019, In: European Journal of Pharmacology. 843, p. 55-65 11 p.

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Raw Cow's Milk Reduces Allergic Symptoms in a Murine Model for Food Allergy-A Potential Role For Epigenetic Modifications

Abbring, S., Wolf, J., Ayechu-Muruzabal, V., Diks, M. A. P., Alhamwe, B. A., Alhamdan, F., Harb, H., Renz, H., Garn, H., Garssen, J., Potaczek, D. P. & van Esch, B. C. A. M., 25 Jul 2019, In: Nutrients. 11, 8, 15 p., 1721.

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Suppression of Food Allergic Symptoms by Raw Cow's Milk in Mice is Retained after Skimming but Abolished after Heating the Milk-A Promising Contribution of Alkaline Phosphatase

Abbring, S., Ryan, J. T., Diks, M. A. P., Hols, G., Garssen, J. & van Esch, B. C. A. M., 30 Jun 2019, In: Nutrients. 11, 7, 18 p., 1499.

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2018

Abnormal Responses to Local Esophageal Food Allergen Injections in Adult Patients With Eosinophilic Esophagitis

Warners, M. J., Terreehorst, I., Van den Wijngaard, R. M., Akkerdaas, J. H., van Esch, B. C. A. M., van Ree, R., Versteeg, S. A., Smout, A. J. P. M. & Bredenoord, A. J., Jan 2018, In: Gastroenterology. 154, 1, p. 57-60.e2 6 p.

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Dietary Supplementation with Non-Digestible Oligosaccharides Reduces Allergic Symptoms and Supports Low Dose Oral Immunotherapy in a Peanut Allergy Mouse Model

Wagenaar, L., Bol-Schoenmakers, M., Giustarini, G., Vonk, M. M., van Esch, B. C. A. M., Knippels, L. M. J., Garssen, J., Smit, J. J. & Pieters, R. H. H., Oct 2018, In: Molecular Nutrition & Food Research. 62, 20, 9 p., 1800369.

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IL-10 Receptor or TGF-β Neutralization Abrogates the Protective Effect of a Specific Nondigestible Oligosaccharide Mixture in Cow-Milk-Allergic Mice

Kerperien, J., Veening-Griffioen, D., Wehkamp, T., van Esch, B. C. A. M., Hofman, G. A., Cornelissen, P., Boon, L., Jeurink, P. V., Garssen, J., Knippels, L. M. J. & Willemsen, L. E. M., 1 Aug 2018, In: Journal of Nutrition. 148, 8, p. 1372-1379 8 p.

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Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells

Li, M., van Esch, B. C. A. M., Wagenaar, G. T. M., Garssen, J., Folkerts, G. & Henricks, P. A. J., 15 Jul 2018, In: European Journal of Pharmacology. 831, p. 52-59 8 p.

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The Anti-inflammatory Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Stimulated Endothelial Cells via Activation of GPR41/43 and Inhibition of HDACs

Li, M., van Esch, B. C. A. M., Henricks, P. A. J., Folkerts, G. & Garssen, J., 23 May 2018, In: Frontiers in Pharmacology. 9, 533.

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Time and Concentration Dependent Effects of Short Chain Fatty Acids on Lipopolysaccharide- or Tumor Necrosis Factor α-Induced Endothelial Activation

Li, M., van Esch, B. C. A. M., Henricks, P. A. J., Garssen, J. & Folkerts, G., 19 Mar 2018, In: Frontiers in Pharmacology. 9, 233.

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2017

A dietary intervention with non-digestible oligosaccharides and partial hydrolysed whey protein prevents the onset of food allergic symptoms in mice

van Esch, B. C. A. M., Kostadinova, A. I., Garssen, J., Willemsen, L. E. M. & Knippels, L. M. J., 1 Mar 2017, In: PharmaNutrition. 5, 1, p. 1-7 7 p.

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A Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates Partial Non-Responsiveness to Whey Protein in Mice Orally Exposed to β-Lactoglobulin-Derived Peptides

Kostadinova, A. I., Meulenbroek, L. A. P. M., van Esch, B. C. A. M., Hofman, G. A., Garssen, J., Willemsen, L. E. M. & Knippels, L. M. J., 12 Jan 2017, In: Frontiers in Immunology. 7, 11 p., 673.

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Dietary Intervention with β-Lactoglobulin-Derived Peptides and a Specific Mixture of Fructo-Oligosaccharides and Bifidobacterium breve M-16V Facilitates the Prevention of Whey-Induced Allergy in Mice by Supporting a Tolerance-Prone Immune Environment

Kostadinova, A. I., Pablos-Tanarro, A., Diks, M. A. P., van Esch, B. C. A. M., Garssen, J., Knippels, L. M. J. & Willemsen, L. E. M., 2017, In: Frontiers in Immunology. 8, p. 1303

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Improved Efficacy of Oral Immunotherapy Using Non-Digestible Oligosaccharides in a Murine Cow's Milk Allergy Model: A Potential Role for Foxp3+Regulatory T Cells

Vonk, M. M., Diks, M. A. P., Wagenaar, L., Smit, J. J., Pieters, R. H. H., Garssen, J., van Esch, B. C. A. M. & Knippels, L. M. J., 29 Sept 2017, In: Frontiers in Immunology. 8, 15 p., 1230.

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Partially hydrolyzed whey proteins prevent clinical symptoms in a cow's milk allergy mouse model and enhance regulatory T and B cell frequencies

Kiewiet, M. B. G., van Esch, B. C. A. M., Garssen, J., Faas, M. M. & Vos, P., Nov 2017, In: Molecular Nutrition and Food Research. 61, 11, 12 p., 1700340.

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Raw Cow's Milk Prevents the Development of Airway Inflammation in a Murine House Dust Mite-Induced Asthma Model

Abbring, S., Verheijden, K. A. T., Diks, M. A. P., Leusink - Muis, T., Hols, G., Baars, T., Garssen, J. & van Esch, B. C. A. M., 28 Aug 2017, In: Frontiers in Immunology. 8, p. 1045

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The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models

Vonk, M. M., Wagenaar, L., Pieters, R. H. H., Knippels, L. M. J., Willemsen, L. E. M., Smit, J. J., van Esch, B. C. A. M. & Garssen, J., 29 Sept 2017, In: Clinical and Translational Allergy. 7, 1, 13 p., 35.

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2016

Post-sensitization administration of non-digestible oligosaccharides and Bifidobacterium breve M-16V reduces allergic symptoms in mice

van Esch, B. C. A. M., Abbring, S., Diks, M. A. P., Dingjan, G. M., Harthoorn, L. F., Vos, A. P. & Garssen, J., Jun 2016, In: Immunity, inflammation and disease. 4, 2, p. 155-165 11 p.

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The mycotoxin deoxynivalenol facilitates allergic sensitization to whey in mice

Bol-Schoenmakers, M., Braber, S., Akbari, P., de Graaff, P., van Roest, M., Kruijssen, L., Smit, J. J., van Esch, B. C. A. M., Jeurink, P. V., Garssen, J., Fink-Gremmels, J. & Pieters, R. H. H., Nov 2016, In: Mucosal Immunology.

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2015

Increased intake of vegetable oil rich in n-6 PUFA enhances allergic symptoms and prevents oral tolerance induction in whey-allergic mice

van den Elsen, L. W. J., van Esch, B. C. A. M., Dingjan, G. M., Hofman, G. A., Garssen, J. & Willemsen, L. E. M., 28 Aug 2015, In: British Journal of Nutrition. 114, 4, p. 577-585 9 p.

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Supplementation of Mice with Specific Nondigestible Oligosaccharides during Pregnancy or Lactation Leads to Diminished Sensitization and Allergy in the Female Offspring

Hogenkamp, A., Knippels, L. M. J., Garssen, J. & van Esch, B. C. A. M., 2015, In: Journal of Nutrition. 145, 5, p. 996-1002 7 p.

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2014

Allergenicity assessment of hydrolysed infant formulas; Comparison of a guinea pig and a mouse model for cow's milk allergy

Van Esch, B. C. A. M., Van Bilsen, J. H. M., Van Gros-Hest, M., Jeurink, P. V., Garssen, J., Smit, J. J., Pieters, R. H. H. & Knippels, L. M. J., 1 Sept 2014, In: Allergy. 69, p. 267 1 p.

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A novel synbiotic concept derived from cow's milk-free source materials reduced allergic symptoms in preventive and therapeutic models for hen's egg allergy

Van Esch, B. C. A. M., Diks, M. A. P., Dingjan, G. A., Harthoorn, L. F., Garssen, J. & Vos, A. P., 1 Sept 2014, In: Allergy. 69, p. 62-63 2 p.

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DHA-Rich Tuna Oil Effectively Suppresses Allergic Symptoms in Mice Allergic to Whey or Peanut

van den Elsen, L. W., Bol-Schoenmakers, M., van Esch, B. C., Hofman, G. A., van de Heijning, B. J., Pieters, R. H., Smit, J. J., Garssen, J. & Willemsen, L. E., Dec 2014, In: Journal of Nutrition. 144, 12, p. 1970-6 7 p.

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Non-digestible oligosaccharides modulate intestinal immune activation and suppress cow's milk allergic symptoms

Kerperien, J., Jeurink, P. V., Wehkamp, T., van der Veer, A., van de Kant, H. J. G., Hofman, G. A., van Esch, E. C. A. M., Garssen, J., Willemsen, L. E. M. & Knippels, L. M. J., Dec 2014, In: Pediatric Allergy and Immunology. 25, 8, p. 747-754 8 p.

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2013

CD25+ regulatory T cells transfer n-3 long chain polyunsaturated fatty acids-induced tolerance in mice allergic to cow's milk protein

Van Den Elsen, L. W. J., Meulenbroek, L. A. P. M., Van Esch, B. C. A. M., Hofman, G. A., Boon, L., Garssen, J. & Willemsen, L. E. M., 1 Dec 2013, In: Allergy. 68, 12, p. 1562-1570 9 p.

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Dietary intervention with specific nondigestible oligosaccharides and Bifidobacterium breve M-16V support the development of tolerogenic DC

De Kivit, S., Kerperien, J., Morgan, M. E., Kostadinova, A. I., Bouwknegt, K., Hofman, G. A., Van Esch, B. C. A. M., Knippels, L. M. J., Kraneveld, A. D., Willemsen, L. E. M. & Garssen, J., 1 Sept 2013, In: Allergy. 68, p. 94 1 p.

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Dietary long chain n-3 polyunsaturated fatty acid induced regulatory T-cells contribute to the prevention of oral sensitization to cow's milk protein in mice

Van Den Elsen, L., Van Esch, B., Hofman, G., Van De Heijning, B., Garssen, J. & Willemsen, L., 25 Jul 2013, In: Clinical and Translational Allergy. 3

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Dietary long chain n-3 polyunsaturated fatty acids prevent allergic sensitization to cow's milk protein in mice

Van den Elsen, L. W. J., Van Esch, B. C. A. M., Hofman, G. A., Kant, J., Van de Heijning, B. J. M., Garssen, J. & Willemsen, L. E. M., 1 Jul 2013, In: Clinical and Experimental Allergy. 43, 7, p. 798-810 13 p.

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Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas

van Esch, E. C. A. M., van Bilsen, J. H. M., Jeurink, P., Penninks, A. H., Smit, J. J., Pieters, R. H. H., Knippels, L. M. & Garssen, J., 2013, In: Toxicology Letters. 220, 1, p. 95-102 8 p.

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Betty van Esch

Research output

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