Research output per year
Research output per year
- 42 results
Search results
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2025
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Segeren, H. A., Wierenga, K. A., Riemers, F. M., van Liere, E. A. & Westendorp, B., 26 Feb 2025, (E-pub ahead of print) In: Molecular Oncology.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
2024
A reverse brake for the cell cycle
Westendorp, B., 2 May 2024, In: Science (New York, N.Y.). 384, 6695, p. 512-513 2 p.Research output: Contribution to journal › Article › Academic › peer-review
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Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection
Veth, T. S., Nouwen, L. V., Zwaagstra, M., Lyoo, H., Wierenga, K. A., Westendorp, B., Altelaar, M. A. F. M., Berkers, C., van Kuppeveld, F. J. M. & Heck, A. J. R., May 2024, In: Molecular and Cellular Proteomics. 23, 5, 100757.Research output: Contribution to journal › Article › Academic › peer-review
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Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage
Yetkin-Arik, B., Jansen, S. A., Varderidou-Minasian, S., Westendorp, B., Skarp, K.-P., Altelaar, M., Lindemans, C. A. & Lorenowicz, M. J., 29 Apr 2024, In: Stem cell research & therapy. 15, 1, 1 p., 125.Research output: Contribution to journal › Article › Academic › peer-review
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MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C
Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wubbolts, R. W., Wu, W., van Putten, J. P. M. & Strijbis, K., Mar 2024, In: Journal of Cell Science. 137, 5Research output: Contribution to journal › Article › Academic › peer-review
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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Segeren, H. A., Wierenga, K. A., Riemers, F. M., Liere, E. A. V. & Westendorp, B., 28 Mar 2024, bioRxiv, 30 p.Research output: Working paper › Preprint › Academic
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2023
Editorial: The role of E2F transcription factors in cancer
Iglesias-Ara, A. & Westendorp, B., 2023, In: Frontiers in Oncology. 13, p. 1-2 2 p., 1355610.Research output: Contribution to journal › Article › Academic › peer-review
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Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface
Chatterjee, M., Huang, L. Z. X., Mykytyn, A. Z., Wang, C., Lamers, M. M., Westendorp, B., Wubbolts, R. W., van Putten, J. P. M., Bosch, B.-J., Haagmans, B. L. & Strijbis, K., Aug 2023, In: PLoS Pathogens. 19, 8, 24 p., e1011571.Research output: Contribution to journal › Article › Academic › peer-review
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Inferring single-cell protein levels and cell cycle behavior in heterogeneous cell populations
Thijssen, B., Segeren, H. A., Liu, Q., Wessels, L. F. A. & Westendorp, B., 26 Aug 2023, bioRxiv, p. 1-27, 27 p.Research output: Working paper › Preprint › Academic
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2022
CDC6: A novel canine tumour biomarker detected in circulating extracellular vesicles
Andriessen, A., Bongiovanni, L., Driedonks, T. A. P., van Liere, E., Seijger, A., Hegeman, C. V., van Nimwegen, S. A., Galac, S., Westendorp, B., Nolte-T Hoen, E. N. M. & de Bruin, A., Jun 2022, In: Veterinary and Comparative Oncology. 20, 2, p. 381-392Research output: Contribution to journal › Article › Academic › peer-review
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Inhibition of polyploidization in Pten-deficient livers reduces steatosis
Moreno, E., Matondo, A. B., Bongiovanni, L., van de Lest, C. H. A., Molenaar, M. R., Toussaint, M. J. M., van Essen, S. C., Houweling, M., Helms, J. B., Westendorp, B. & de Bruin, A., Nov 2022, In: Liver International. 42, 11, p. 2442-2452 11 p.Research output: Contribution to journal › Article › Academic › peer-review
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Mechanisms used by cancer cells to tolerate drug-induced replication stress
Segeren, H. A. & Westendorp, B., 28 Sept 2022, In: Cancer Letters. 544, p. 1-10 10 p., 215804.Research output: Contribution to journal › Review article › peer-review
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MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C
Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wu, W., Putten, J. P. M. V. & Strijbis, K., 27 Oct 2022, bioRxiv, p. 1-30.Research output: Working paper › Preprint › Academic
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Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53
Segeren, H. A., van Liere, E. A., Riemers, F. M., de Bruin, A. & Westendorp, B., 6 May 2022, In: Oncogene. 41, 19, p. 2719-2733 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage
Wierenga, K. A., Riemers, F. M., Westendorp, B., Harkema, J. R. & Pestka, J. J., 3 Nov 2022, In: Frontiers in Immunology. 13, 22 p., 993614.Research output: Contribution to journal › Article › Academic › peer-review
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The RAS oncogene hits the brake pedal on P53
Westendorp, B., 8 Apr 2022Research output: Non-textual form › Web publication/site › Other research output
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2021
Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context
Moreno, E., Pandit, S. K., Toussaint, M. J. M., Bongiovanni, L., Harkema, L., van Essen, S. C., van Liere, E. A., Westendorp, B. & de Bruin, A., 1 May 2021, In: Cancers. 13, 9, p. 1-14 14 p., 2033.Research output: Contribution to journal › Article › Academic › peer-review
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Collection of cells for single-cell RNA sequencing using high-resolution fluorescence microscopy
Segeren, H. A., Andree, K. C., Oomens, L. & Westendorp, B., 17 Sept 2021, In: STAR Protocols. 2, 3, p. 1-11 100718.Research output: Contribution to journal › Article › Academic › peer-review
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E2F7 is a potent inhibitor of liver tumor growth in adult mice
Moreno, E., Toussaint, M. J. M., van Essen, S. C., Bongiovanni, L., van Liere, E. A., Koster, M. H., Yuan, R., van Deursen, J., Westendorp, B. & de Bruin, A., Jan 2021, In: Hepatology. 73, 1, p. 303-317Research output: Contribution to journal › Article › Academic › peer-review
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Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation
Roukens, M. G., Frederiks, C. L., Seinstra, D., Braccioli, L., Khalil, A. A., Pals, C., De Neck, S., Bornes, L., Beerling, E., Mokry, M., de Bruin, A., Westendorp, B., van Rheenen, J. & Coffer, P. J., 11 Nov 2021, In: Oncogene. 40, 45, p. 6343-6353 11 p.Research output: Contribution to journal › Article › Academic › peer-review
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The glycosylated extracellular domain of MUC1 protects against SARS-CoV-2 infection at the respiratory surface
Chatterjee, M., Huang, L. Z. X., Wang, C., Mykytyn, A. Z., Westendorp, B., Wubbolts, R. W., Bosch, B.-J., Haagmans, B. L., Putten, J. P. M. V. & Strijbis, K., 29 Oct 2021, bioRxiv, 23 p.Research output: Working paper › Preprint › Academic
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2020
E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
Sladky, V. C., Knapp, K., Soratroi, C., Heppke, J., Eichin, F., Rocamora-Reverte, L., Szabo, T. G., Bongiovanni, L., Westendorp, B., Moreno, E., van Liere, E. A., Bakker, B., Spierings, D. C. J., Wardenaar, R., Pereyra, D., Starlinger, P., Schultze, S., Trauner, M., Stojakovic, T. & Scharnagl, H. & 4 others, , 10 Feb 2020, In: Developmental Cell. 52, 3, p. 335-349.e7 22 p.Research output: Contribution to journal › Article › Academic › peer-review
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Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell Cycle Exit after DNA Damage
Segeren, H. A., van Rijnberk, L., Moreno, E., Riemers, F., Yuan, R., Wubbolts, R., de Bruin, A. & Westendorp, B., 21 Apr 2020, SSRN.Research output: Working paper › Preprint › Academic
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Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage
Segeren, H. A., van Rijnberk, L. M., Moreno, E., Riemers, F. M., van Liere, E. A., Yuan, R., Wubbolts, R., de Bruin, A. & Westendorp, B., 1 Dec 2020, In: Cell Reports. 33, 9, 21 p., 108449.Research output: Contribution to journal › Article › Academic › peer-review
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PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis
Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C. J., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N. & Villunger, A., 1 Jan 2020, In: EMBO Reports. 21, p. 1-16 e50893.Research output: Contribution to journal › Article › Academic › peer-review
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2019
Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression
Yuan, R., Liu, Q., Segeren, H. A., Yuniati, L., Guardavaccaro, D., Lebbink, R. J., Westendorp, B. & de Bruin, A., 15 Oct 2019, In: EMBO Journal. 38, 14 p., e101430.Research output: Contribution to journal › Article › Academic › peer-review
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2018
A single cell approach to explore replication stress tolerance in cancer cells as therapeutic target.
Segeren, H. A., de Bruin, A. & Westendorp, B., 2018.Research output: Contribution to conference › Poster › Academic
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Atypical E2Fs inhibit tumor angiogenesis
Weijts, B. G. M. W., Westendorp, B., Hien, B. T., Martínez-López, L. M., Zijp, M., Thurlings, I., Thomas, R. E., Schulte-Merker, S., Bakker, W. J. & de Bruin, A., 11 Jan 2018, In: Oncogene. 37, p. 271-276 6 p.Research output: Contribution to journal › Article › Academic › peer-review
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Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest
Yuan, R., Vos, H., van Es, R. M., Chen, J., Burgering, B. M. T., Westendorp, B. & de Bruin, A., 1 Mar 2018, In: EMBO Journal. 37, 5, 17 p., e97877.Research output: Contribution to journal › Article › Academic › peer-review
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DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells
Kruitwagen, H. S., Westendorp, B., Viebahn, C. S., Post, K., van Wolferen, M. E., Oosterhoff, L. A., Egan, D. A., Delabar, J.-M., Toussaint, M. J., Schotanus, B. A., de Bruin, A., Rothuizen, J., Penning, L. C. & Spee, B., 15 Jan 2018, In: Stem Cells and Development. 27, 2, p. 133-146 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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Kanker bij dieren: hoe voelt een tumor?
Westendorp, B., 28 Oct 2018Research output: Other contribution › Popular
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2017
Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
Kent, L. N., Bae, S., Tsai, S. Y., Tang, X., Srivastava, A., Koivisto, C., Martin, C. K., Ridolfi, E., Miller, G. C., Zorko, S. M., Plevris, E., Hadjiyannis, Y., Perez, M., Nolan, E., Kladney, R., Westendorp, B., De Bruin, A., Fernandez, S., Rosol, T. J. & Pohar, K. S. & 2 others, , 1 Mar 2017, In: Journal of Clinical Investigation. 127, 3, p. 830-842 13 p.Research output: Contribution to journal › Article › Academic › peer-review
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Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
Thurlings, I., Martínez-López, L. M., Westendorp, B., Zijp, M., Kuiper, R., Tooten, P., Kent, L. N., Leone, G., Vos, H. J., Burgering, B. & de Bruin, A., 2017, In: Oncogene. 36, p. 829-839Research output: Contribution to journal › Article › Academic › peer-review
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2016
E2f8 mediates tumor suppression in postnatal liver development
Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H. Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., Koivisto, C., Martin, C. K., Cuitino, M. C., Perez, M., Clouse, J. M., Chokshi, V., Shinde, N., Kladney, R., Sun, D. & Perez-Castro, A. & 13 others, , 1 Aug 2016, In: Journal of Clinical Investigation. 126, 8, p. 2955-2969 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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Feedback regulation between atypical E2Fs and APC/C Cdh1 coordinates cell cycle progression
Boekhout, M., Yuan, R., Wondergem, A. P., Segeren, H. A., Van Liere, E. A., Awol, N., Jansen, I., Wolthuis, R. M., De Bruin, A. & Westendorp, B., 2016, In: EMBO Reports. 17, 3, p. 414-427 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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2013
HIF proteins connect the RB-E2F factors to angiogenesis
Bakker, W. J., Weijts, B. G. M. W., Westendorp, B. & de Bruin, A., 2013, In: Transcription. 4, p. 62-66 5 p.Research output: Contribution to journal › Article › Academic › peer-review
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Physiological significance of polyploidization in mammalian cells
Pandit, S. K., Westendorp, B. & de Bruin, A., 2013, In: Trends in Cell Biology. 23, 11, p. 556-566 11 p.Research output: Contribution to journal › Article › Academic › peer-review
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2012
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1
Weijts, B. G. M. W., Bakker, W. J., Cornelissen, P. W. A., Liang, K. A., Schaftenaar, F. A., Westendorp, B., Wolf, C. A., Paciejewska, M., Scheele, C. L., Kent, L., Leone, G., Schulte-Merker, S. & de Bruin, A., 2012, In: EMBO Journal. 19, p. 3871-3884 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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E2F7 represses a network of oscillating cell cycle genes to control S-phase progression
Westendorp, B., Mokry, M., Groot Koerkamp, M. J., Holstege, F. C. P., Cuppen, E. P. J. G. & de Bruin, A., 2012, In: Nucleic Acids Research. 40, 8, p. 3511-3523 13 p.Research output: Contribution to journal › Article › Academic › peer-review
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E2F8 is essential for polyploidization in mammalian cells
Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H. & de Bruin, A., Nov 2012, In: Nature Cell Biology. 14, 11, p. 1181-1191 11 p.Research output: Contribution to journal › Article › Academic › peer-review
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Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum.
Nader, M., Westendorp, B., Hawari, O., Salih, M., Stewart, A., Leenen, F. & Tuana, B., 1 Mar 2012, In: American journal of physiology. Heart and circulatory physiology. 302, 5, p. H1138-H1145Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy
Westendorp, B., Major, J. L., Nader, M., Salih, M., Leenen, F. H. & Tuana, B. S., Jun 2012, In: FASEB Journal. 26, 6, p. 2569-2579 2 p.Research output: Contribution to journal › Article › Academic › peer-review