Research Department VM - Biomolecular Health Sciences - Research output

2025

Acanthamoeba castellanii trophozoites need oxygen for normal functioning and lipids are their preferred substrate, offering new possibilities for treatment

Sarink, M. J., Mykytyn, A. Z., Jedidi, A., Houweling, M., Brouwers, J. F., Ruijter, G., Verbon, A., van Hellemond, J. J. & Tielens, A. G. M., Jan 2025, In: International Journal for Parasitology. 55, 1, p. 35-44 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Cellular crosstalk promotes hepatic progenitor cell proliferation and stellate cell activation in 3D co-culture

Haaker, M. W., Chang, J.-C., Chung, B. K., Pieper, T. S., Noé, F., Wang, T., Geijsen, N., Houweling, M., Wolfrum, C., Vaandrager, A. B., Melum, E., Spee, B. & Helms, J. B., 2025, In: Cellular and Molecular Gastroenterology and Hepatology. 19, 5, 101472.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Maternal exposure to purified versus grain-based diet during early lactation in mice affects offspring growth and reduces responsivity to Western-style diet challenge in adulthood

Rakhshandehroo, M., Harvey, L., de Bruin, A., Timmer, E., Lohr, J., Tims, S. & Schipper, L., 9 Jan 2025, In: Journal of Developmental Origins of Health and Disease. 16, e3.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Metabolic profiling of patient-derived organoids reveals nucleotide synthesis as a metabolic vulnerability in malignant rhabdoid tumors

Kes, M. M. G., Morales-Rodriguez, F., Zaal, E. A., de Souza, T., Proost, N., van de Ven, M., van den Heuvel-Eibrink, M. M., Jansen, J. W. A., Berkers, C. R. & Drost, J., 21 Jan 2025, In: Cell Reports Medicine. 6, 1, 101878.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers

Ali, T. T., Merghani, M., Al-Azzani, M., Gatzemeier, L. M., Hoppert, M., Kaloyanova, D., Outeiro, T. F., Neumann, P., Popova, B. & Braus, G. H., 5 May 2025, In: European Journal of Medicinal Chemistry. 289, 14 p., 117452.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis

Halmos, B., La Rose, A. M., Methorst, D., Groenen, A. G., Nakládal, D., Bazioti, V., Koster, M. H., Kloosterhuis, N. J., Buiten, A. V., Schouten, E. M., Huijkman, N. C. A., Langelaar-Makkinje, M., Bongiovanni, L., De Neck, S. M., de Bruin, A., Buikema, H., Deelman, L. E., van den Heuvel, M. C., Kuipers, F. & de Jong, I. J. & 4 others, Sluimer, J. C., Jørgensen, H. F., Henning, R. H. & Westerterp, M., 28 Feb 2025, In: Circulation Research. 136, 5, p. 491-507 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Stable Isotope Tracing Experiments Using LC-MS

Zaal, E. A., Jansen, J. W. A. & Berkers, C. R., 2025, In: Methods in molecular biology (Clifton, N.J.). 2855, p. 103-116 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Segeren, H. A., Wierenga, K. A., Riemers, F. M., van Liere, E. A. & Westendorp, B., 26 Feb 2025, (E-pub ahead of print) In: Molecular Oncology.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2024

AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism

Brombacher, E. C., Patente, T. A., van der Ham, A. J., Moll, T. J. A., Otto, F., Verheijen, F. W. M., Zaal, E. A., de Ru, A. H., Tjokrodirijo, R. T. N., Berkers, C. R., van Veelen, P. A., Guigas, B. & Everts, B., 7 Oct 2024, In: The Journal of cell biology. 223, 10, e202401024.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

APAVAC Immunotherapy for the Adjuvant Treatment of a Canine Mucosal Melanoma

Rinaldi, V., Bongiovanni, L., Crisi, P. E., Vignoli, M., Peli, R. E., Masci, S., Boari, A. & Finotello, R., 6 Dec 2024, In: Veterinary Sciences. 11, 12, 628.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

A reverse brake for the cell cycle

Westendorp, B., 2 May 2024, In: Science (New York, N.Y.). 384, 6695, p. 512-513 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants

Yang, C., Pataskar, A., Feng, X., Montenegro Navarro, J., Paniagua, I., Jacobs, J. J. L., Zaal, E. A., Berkers, C. R., Bleijerveld, O. B. & Agami, R., 16 May 2024, In: Molecular Cell. 84, 10, p. 1904-1916.e7

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection

Veth, T. S., Nouwen, L. V., Zwaagstra, M., Lyoo, H., Wierenga, K. A., Westendorp, B., Altelaar, M. A. F. M., Berkers, C., van Kuppeveld, F. J. M. & Heck, A. J. R., May 2024, In: Molecular and Cellular Proteomics. 23, 5, 100757.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Between Melpomene and Thalia: The multiple faces of hepatic stellate cells and lipids in the liver

Haaker, M. W., 16 May 2024, Utrecht: Utrecht University. 240 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

B-Flow and Contrast-Enhanced Ultrasound (CEUS) Features of Subcutaneous Masses and Nodular Lesions in Dogs

De Bonis, A., Simeoni, F., Paolini, A., Rosto, M., Del Signore, F., Bongiovanni, L., Bianchi, A., Tamburro, R. & Vignoli, M., 21 Oct 2024, In: Veterinary Sciences. 11, 10, 12 p., 516.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Bridging the gap: advancing cancer cell culture to reveal key metabolic targets

Kes, M. M. G., Berkers, C. R. & Drost, J., 17 Sept 2024, In: Frontiers in Oncology. 14, 11 p., 1480613.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Cannabinoid receptor-2 expression in canine multicentric diffuse large B-cell lymphoma: An immunohistochemical, digital pathology and clinical analysis

Rinaldi, V., Ressel, L., Bongiovanni, L., Crisi, P. E., Boari, A., Killick, D., Chiocchetti, R. & Finotello, R., Nov 2024, In: Research in Veterinary Science. 180, 6 p., 105411.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice

Heida, A., van Dijk, T., Smit, M., Koehorst, M., Koster, M., Kloosterhuis, N., Havinga, R., Bloks, V. W., Wolters, J. C., de Bruin, A., Kuivenhoven, J. A., de Boer, J. F., Kuipers, F. & van de Sluis, B., Mar 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 2, p. 1-11 11 p., 159445.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Deciphering metabolic crosstalk in context: lessons from inflammatory diseases

Verheijen, F. W. M., Tran, T. N. M., Chang, J.-C., Broere, F., Zaal, E. A. & Berkers, C. R., Jul 2024, In: Molecular Oncology. 18, 7, p. 1759-1776 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

Early activation of hepatic stellate cells induces rapid initiation of retinyl ester breakdown while maintaining lecithin: Retinol acyltransferase (LRAT) activity

Haaker, M. W., Goossens, V., Hoogland, N. A. N., van Doorne, H., Wang, Z., Jansen, J. W. A., Kaloyanova, D. V., van de Lest, C. H. A., Houweling, M., Vaandrager, A. B. & Helms, J. B., Oct 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 7, 10 p., 159540.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity

Kovacevic, I., Schmidt, P. H., Kowalski, A., Helms, B. J., Lest, C. H. A. V. D., Kluttig, A. & Posern, G., 3 Jun 2024, In: Cell Communication and Signaling. 22, 1, p. 1-21 21 p., 304.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T-cells

Zhang, X., Greve, P. F., Minh, T. T. N., Wubbolts, R., Demir, A. Y., Zaal, E. A., Berkers, C. R., Boes, M. & Stoorvogel, W., Jul 2024, In: Journal of Extracellular Vesicles. 13, 7, p. 1-22 22 p., e12457.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Gut Microbes in Parkinson's Disease

Markidi, A., Elford, J. D., Berkers, C., Kraneveld, A. D. & Perez-Pardo, P., 2024, The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota. 2 ed. p. 217-240 24 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Histomorphological evaluation of thermal injury following palatoplasty performed with CO 2 laser or LigaSure device in dogs with brachycephalic obstructive airway syndrome.

Tamburro, R., Bianchi, A., Paolini, A., Bongiovanni, L., Della Salda, L., Collivignarelli, F., Niebauer, G. W., Ceballos, J. L., Teofani, M. & Bussadori, R., Oct 2024, In: The Veterinary Journal. 307, 106195.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis

de Kivit, S., Mensink, M., Kostidis, S., Derks, R. J. E., Zaal, E. A., Heijink, M., Verleng, L. J., de Vries, E., Schrama, E., Blomberg, N., Berkers, C. R., Giera, M. & Borst, J., 24 Sept 2024, In: Cell Reports. 43, 9, 114681.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Intracellular localisation and extracellular release of Y RNA and Y RNA binding proteins

Driedonks, T. A. P., Ressel, S., Tran Ngoc Minh, T., Buck, A. H. & Nolte-‘t Hoen, E. N. M., Jan 2024, In: Journal of Extracellular Biology. 3, 1, 16 p., e123.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment

Sendino Garví, E., van Slobbe, G. J. J., Zaal, E. A., de Baaij, J. H. F., Hoenderop, J. G., Masereeuw, R., Janssen, M. J. & van Genderen, A. M., 26 Aug 2024, In: Stem cell research & therapy. 15, 1, 268.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Lipidome profiling of neutrophil-derived extracellular vesicles unveils their contribution to the ensemble of synovial fluid-derived extracellular vesicles during joint inflammation

Varela, L., Mol, S., Taanman-Kueter, E. W., Ryan, S. E., Taams, L. S., de Jong, E., van Weeren, P. R., van de Lest, C. H. A. & Wauben, M. H. M., Oct 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 7, 159534.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Loss of HD-PTP function results in lipodystrophy, defective cellular signaling, and altered lipid homeostasis

Schultz, D. F., Davies, B. A., Payne, J. A., Martin, C. P., Minard, A. Y., Childs, B. G., Zhang, C., Jeganathan, K. B., Sturmlechner, I., White, T. A., de Bruin, A., Harkema, L., Chen, H., Davies, M. A., Jachim, S., LeBrasseur, N. K., Piper, R. C., Li, H., Baker, D. J. & van Deursen, J. & 2 others, Billadeau, D. D. & Katzmann, D. J., Sept 2024, In: Journal of Cell Science. 137, 18, jcs262032.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage

Yetkin-Arik, B., Jansen, S. A., Varderidou-Minasian, S., Westendorp, B., Skarp, K.-P., Altelaar, M., Lindemans, C. A. & Lorenowicz, M. J., 29 Apr 2024, In: Stem cell research & therapy. 15, 1, 1 p., 125.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

MISEV Consortium, Welsh, J. A., Goberdhan, D. C. I., O'Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q.-L., Hill, A. F., Lenassi, M., Lim, S. K., Mahoney, M. G., Mohanty, S., Möller, A. & Nieuwland, R. & 30 others, Ochiya, T., Sahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Colombo, F., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Hendrix, A., Ivanov, A. R., Jovanovic-Talisman, T., Kruh-Garcia, N. A., Ku'ulei-Lyn Faustino, V., Kyburz, D., Lässer, C., Lennon, K. M., Lötvall, J., van Herwijnen, M. J. C., Wauben, M. H. M. & Stoorvogel, W., Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Modulation of nucleotide metabolism by picornaviruses

Nouwen, L. V., Breeuwsma, M., Zaal, E. A., van de Lest, C. H. A., Buitendijk, I., Zwaagstra, M., Balić, P., Filippov, D. V., Berkers, C. R. & van Kuppeveld, F. J. M., Mar 2024, In: PLoS Pathogens. 20, 3 March, e1012036.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C

Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wubbolts, R. W., Wu, W., van Putten, J. P. M. & Strijbis, K., Mar 2024, In: Journal of Cell Science. 137, 5

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4⁺ T cells through incorporation into membrane lipids

von Hegedus, J. H., de Jong, A. J., Hoekstra, A. T., Spronsen, E., Zhu, W., Cabukusta, B., Kwekkeboom, J. C., Heijink, M., Bos, E., Berkers, C. R., Giera, M. A., Toes, R. E. M. & Ioan-Facsinay, A., Sept 2024, In: European Journal of Immunology. 54, 9, 2350685.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane

Bizerra, P. F. V., Gilglioni, E. H., Li, H. L., Go, S., Oude Elferink, R. P. J., Verhoeven, A. J. & Chang, J. C., Jan 2024, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1871, 1, 17 p., 119585.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Oral β-RA induces metabolic rewiring leading to the rescue of diet-induced obesity

Díaz-Casado, M. E., González-García, P., López-Herrador, S., Hidalgo-Gutiérrez, A., Jiménez-Sánchez, L., Barriocanal-Casado, E., Bakkali, M., van de Lest, C. H. A., Corral-Sarasa, J., Zaal, E. A., Berkers, C. R. & López, L. C., 1 Oct 2024, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1870, 7, 14 p., 167283.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance

Jiang, X., Baig, A. H., Palazzo, G., Del Pizzo, R., Bortecen, T., Groessl, S., Zaal, E. A., Amaya Ramirez, C. C., Kowar, A., Aviles-Huerta, D., Berkers, C. R., Palm, W., Tschaharganeh, D., Krijgsveld, J. & Loayza-Puch, F., 28 Aug 2024, In: Nature Communications. 15, 1, 16 p., 7458.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Postpartum development of metabolic dysfunction-associated steatotic liver disease in a lean mouse model of gestational diabetes mellitus

Hribar, K., Eichhorn, D., Bongiovanni, L., Koster, M. H., Kloosterhuis, N. J., de Bruin, A., Oosterveer, M. H., Kruit, J. K. & van der Beek, E. M., 25 Jun 2024, In: Scientific Reports. 14, 1, 11 p., 14621.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers

Clarke, E., Varela, L., Jenkins, R. E., Lozano-Andrés, E., Cywińska, A., Przewozny, M., van Weeren, P. R., van de Lest, C. H. A., Peffers, M. & Wauben, M. H. M., Mar 2024, In: Biochemistry and Biophysics Reports. 37, 15 p., 101635.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Pulmonary Thromboembolism and Myocarditis Resulting from a Large Pacing-Lead-Associated Right Ventricular Thrombus in a Dog with Chronic Cough as Presenting Sign

Szatmári, V. & Thomas, R., 24 May 2024, In: Veterinary Sciences. 11, 6, 18 p., 237.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Regulation of progenitor properties and tissue dysfunction by cellular senescence

Brand, T., 27 Nov 2024, Utrecht University. 144 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

File

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma

Wang, Y., Muylaert, C., Wyns, A., Vlummens, P., De Veirman, K., Vanderkerken, K., Zaal, E., Berkers, C., Moreaux, J., De Bruyne, E. & Menu, E., 1 Jan 2024, In: Haematologica. 109, 1, p. 256-271 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose

Xu, Y., Wang, X., Zaal, E. A., Berkers, C. R., Lorent, J. H., Heise, T., Cox, R., Pieters, R. J. & Breukink, E., May 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 4, 11 p., 159467.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Segeren, H. A., Wierenga, K. A., Riemers, F. M., Liere, E. A. V. & Westendorp, B., 28 Mar 2024, bioRxiv, 30 p.

Research output: Working paper › Preprint › Academic

File

Synovial fluid extracellular vesicles as arthritis biomarkers: the added value of lipid-profiling and integrated omics

Varela, L., van de Lest, C. H. A., René van Weeren, P. & Wauben, M. H. M., 13 Jun 2024, In: Extracellular Vesicles and Circulating Nucleic Acids. 5, 2, p. 276-296 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host

Bexkens, M. L., Martin, O. M. F., van den Heuvel, J. M., Schmitz, M. G. J., Teusink, B., Bakker, B. M., van Hellemond, J. J., Haanstra, J. R., Walkinshaw, M. D. & Tielens, A. G. M., Jun 2024, In: International Journal for Parasitology. 54, 7, p. 367-378 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Treatment of intestinal and liver features in cystic fibrosis mice by the osmotic laxative polyethylene glycol

Bertolini, A., Bloks, V. W., Wilmink, M., Bos, E., van de Peppel, I. P., Eilers, R., Prins, S., Thomas, R., de Bruin, A., Verkade, H. & Jonker, J. W., May 2024, In: Journal of Cystic Fibrosis. 23, 3, p. 461-473 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

2023

Acute joint inflammation induces a sharp increase in the number of synovial fluid EVs and modifies their phospholipid profile

Varela, L., van de Lest, C. H. A., Boere, J., Libregts, S. F. W. M., Lozano-Andrés, E., van Weeren, P. R. & Wauben, M. H. M., Oct 2023, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868, 10, 13 p., 159367.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

A novel KCNJ16 kidney organoid model recapitulates the disease phenotype and shows restoration of lipid accumulation upon treatment with statins

Garvi, E. S., Slobbe, G. V. D., Zaal, E. A., Baaij, J. H. F. D., Hoenderop, J., Masereeuw, R., Janssen, M. J. & Genderen, A. M. V., 23 Dec 2023, bioRxiv, p. 1-37, 37 p.

Research output: Working paper › Preprint › Academic

Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential

Lak, N. S. M., Seijger, A., van Zogchel, L. M. J., Gelineau, N. U., Javadi, A., Zappeij-Kannegieter, L., Bongiovanni, L., Andriessen, A., Stutterheim, J., van der Schoot, C. E., de Bruin, A. & Tytgat, G. A. M., 1 Apr 2023, In: Cancers. 15, 7, p. 1-16 16 p., 2108.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Research Department VM - Biomolecular Health Sciences

Research output

Search results