Chemical Biology and Drug Discovery

2025

A comparative cost and qualitative analysis for the transportation of green energy carriers

Kroon, T., Fattahi, A., Dalla Longa, F., Slootweg, J. C. & van der Zwaan, B., 7 Apr 2025, In: Sustainable Energy and Fuels. 9, 7, p. 1773-1785

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Affinity-based covalent sialyltransferase probes enabled by ligand-directed chemistry

Ong, J. Y., Alvarado-Melendez, E. I., Maliepaard, J. C. L., Reiding, K. R. & Wennekes, T., 21 Feb 2025, In: Chemical Science. 16, 7, p. 3336-3344 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Alkyne- and Azide-Functionalised Cyclophellitol Derivatives for Selective Glucuronidase Targeting

Leona Ehren, H., Jongkees, S. A. K. & Wennekes, T., 17 Jan 2025, In: European Journal of Organic Chemistry. 28, 3, e202401076.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Associating structural characteristics to immunomodulating properties of carrot rhamnogalacturonan-I fractions

Desai, K., Dobruchowska, J. M., Elbers, K., Cybulska, J., Zdunek, A., Porbahaie, M., Jansen, E., Van Neerven, J., Albers, R., Wennekes, T., Mercenier, A. & Schols, H. A., 1 Jan 2025, In: Carbohydrate Polymers. 347, 13 p., 122730.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Bisecting N-Acetylglucosamine of the N-Glycan of Immunoglobulin G Does Not Affect Binding to Fc Gamma Receptors

Bosman, G. P., Stoof, I. D., Bastiaansen, H. P., Quarles van Ufford, L., Dobruchowska, J. M., Langenbach, J. W. H., Boruah, B. M., Moremen, K. W., Bentlage, A. E. H., Lissenberg-Thunnissen, S. N., Vidarsson, G. & Boons, G. J., 21 Mar 2025, In: ACS Chemical Biology. 20, 3, p. 680-689 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Divergent Chemoenzymatic Synthesis of Sulfated Ganglio-Oligosaccharides for Probing Ligand Requirements of Glycan Binding Proteins

Bunyatov, M. I., Wolfert, M. A. & Boons, G.-J., 10 Mar 2025, In: Angewandte Chemie-International Edition. 64, 11, 10 p., e202415521.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Laminarins and their derivatives affect dendritic cell activation and their crosstalk with T cells

Christensen, M. D., Allahgholi, L., Dobruchowska, J. M., Moenaert, A., Guðmundsson, H., Friðjónsson, Ó., Karlsson, E. N., Hreggviðsson, G. & Freysdottir, J., May 2025, In: International Journal of Biological Macromolecules. 306, 15 p., 141287.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Profiles of 71 Human Milk Oligosaccharides and Novel Sub-Clusters of Type I Milk: Results from the Ulm SPATZ Health Study

Peng, Z., Siziba, L. P., Mank, M., Stahl, B., Gonsalves, J., Wernecke, D., Rothenbacher, D. & Genuneit, J., 14 Jan 2025, In: Nutrients. 17, 2, 280.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Protein-bound and free glycation compounds in human milk: A comparative study with minimally processed infant formula and pasteurized bovine milk

Arena, S., De Pascale, S., Ciaravolo, V., Monroy, M. M., Gouw, J. W., Stahl, B., Bäuerl, C., Collado, M. C., De Filippo, C., Scaloni, A. & Troise, A. D., 15 Jan 2025, In: Food Chemistry. 463, Pt 2, 14 p., 141265.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Robust and High-Resolution All-Ion Fragmentation LC-ESI-IM-MS Analysis for In-Depth Characterization or Profiling of Up to 200 Human Milk Oligosaccharides

Gonsalves, J., Bauzá-Martinez, J., Stahl, B., Dingess, K. A. & Mank, M., 18 Mar 2025, In: Analytical Chemistry. 97, 10, p. 5563-5574 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Silicon-Based Linkers for Tunable Acid-Sensitive Drug Release from Polymeric Nanoparticles

Timmers, M., Kong, M., Schuckman, P., Meulemans, T., Rijcken, C., Hennink, W. E., Vermonden, T. & Liskamp, R. M. J., 12 Mar 2025, In: Chemistry - A European Journal. 31, 15, e202403589.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors

Ríos Carrasco, M., Lin, T.-H., Zhu, X., Gabarroca García, A., Uslu, E., Liang, R., Spruit, C. M., Richard, M., Boons, G.-J., Wilson, I. A. & de Vries, R. P., 15 Apr 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 16, e2419800122.

Research output: Contribution to journal › Article › Academic › peer-review

2024

2,2-Difluoro Derivatives of Fucose Can Inhibit Cell Surface Fucosylation without Causing Slow Transfer to Acceptors

Liu, Y., Sweet, I. R. & Boons, G.-J., 28 Oct 2024, In: JACS Au. 4, 10, p. 3953–3963 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

A Biomimetic Synthetic Strategy Can Provide Keratan Sulfate I and II Oligosaccharides with Diverse Fucosylation and Sulfation Patterns

Wu, Y., Bosman, G. P., Chapla, D., Huang, C., Moremen, K. W., de Vries, R. P. & Boons, G.-J., 3 Apr 2024, In: Journal of the American Chemical Society. 146, 13, p. 9230-9240 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Antimicrobial and immunomodulatory activities of porcine cathelicidin Protegrin-1

Javed, A., Oedairadjsingh, T., Ludwig, I. S., Wood, T. M., Martin, N. I., Broere, F., Weingarth, M. H. & Veldhuizen, E. J. A., Sept 2024, In: Molecular Immunology. 173, p. 100-109 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Asymmetrical Biantennary Glycans Prepared by a Stop-and-Go Strategy Reveal Receptor Binding Evolution of Human Influenza A Viruses

Ma, S., Liu, L., Eggink, D., Herfst, S., Fouchier, R. A. M., Vries, R. P. D. & Boons, G.-J., 23 Jan 2024, In: JACS Au. 4, 2, p. 607-618 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

A "terminal" case of glycan catabolism: structural and enzymatic characterization of the sialidases of Clostridium perfringens

Medley, B. J., Low, K. E., Irungu, J. D. W., Kipchumba, L., Daneshgar, P., Liu, L., Garber, J. M., Klassen, L., Inglis, G. D., Boons, G.-J., Zandberg, W. F., Abbott, D. W. & Boraston, A. B., Oct 2024, In: Journal of Biological Chemistry. 300, 10, 107750.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Chemical Synthesis of Δ-4,5 Unsaturated Heparan Sulfate Oligosaccharides for Biomarker Discovery

Joshi, A., Chopra, P., Venot, A. & Boons, G.-J., 29 Mar 2024, In: Organic Letters. 26, 12, p. 2462-2466 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Chemoenzymatic synthesis of human natural killer-1-containing glycans and application as serum antibodies probes

Bunyatov, M., Wolfert, M. A., Liu, L., Huizinga, R., Schreurs, M. W. J., Jacobs, B. C. & Boons, G. J., Jan 2024, In: Nature Synthesis. 3, 1, p. 85-98 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Chemo-Enzymatic Synthesis of Isomeric I-branched Polylactosamines using Traceless Blocking Groups

Vos, G. M., Wu, Y., van der Woude, R., de Vries, R. P. & Boons, G.-J., 22 Jan 2024, In: Chemistry-A European Journal. 30, 5, e202302877.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Chemoenzymatic Synthesis of Keratan Sulfate Oligosaccharides Using UDP-Galactose-6-aldehyde To Control Sulfation at Galactosides

Wu, Y., Bosman, G. P., Vos, G. M., Uslu, E., Chapla, D., Huang, C., Moremen, K. W. & Boons, G.-J., 2024, In: Organic Letters. 26, 39, p. 8272–8277 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Chemoenzymatic Synthesis of Tri-antennary N-glycans Terminating in Sialyl-Lewisx Reveals the Importance of Glycan Complexity for Influenza A Virus Receptor Binding

Li, T., Spruit, C. M., Wei, N., Liu, L., Wolfert, M. A., de Vries, R. P. & Boons, G.-J., 6 Jun 2024, In: Chemistry-A European Journal. 30, 32, e202401108.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Complex N-glycans are important for interspecies transmission of H7 influenza A viruses

Spruit, C. M., Palme, D. I., Li, T., Ríos Carrasco, M., Gabarroca García, A., Sweet, I. R., Kuryshko, M., Maliepaard, J. C. L., Reiding, K. R., Scheibner, D., Boons, G.-J., Abdelwhab, E. M. & de Vries, R. P., Apr 2024, In: Journal of Virology. 98, 4, 21 p., e0194123.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation

de Jong, S. P. J., Felix Garza, Z. C., Gibson, J. C., van Leeuwen, S., de Vries, R. P., Boons, G. J., van Hoesel, M., de Haan, K., van Groeningen, L. E., Hulme, K. D., van Willigen, H. D. G., Wynberg, E., de Bree, G. J., Matser, A., Bakker, M., van der Hoek, L., Prins, M., Kootstra, N. A., Eggink, D. & Nichols, B. E. & 3 others, Han, A. X., de Jong, M. D. & Russell, C. A., 18 Jan 2024, In: Nature Communications. 15, 1, p. 1-11 11 p., 591.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Direct and Ultrasensitive Bioluminescent Detection of Intact Respiratory Viruses

Gräwe, A., van der Veer, H., Jongkees, S. A. K., Flipse, J., Rossey, I., de Vries, R. P., Saelens, X. & Merkx, M., 2024, In: ACS Sensors. 9, 10, p. 5550–5560 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Discovery of two non-UDP-mimic inhibitors of O-GlcNAc transferase by screening a DNA-encoded library

Balsollier, C., Bijkerk, S., de Smit, A., van Eekelen, K., Bozovičar, K., Husstege, D., Tomašič, T., Anderluh, M. & Pieters, R. J., Jun 2024, In: Bioorganic Chemistry. 147, 107321.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Full-length single-molecule protein fingerprinting

Filius, M., van Wee, R., de Lannoy, C., Westerlaken, I., Li, Z., Kim, S. H., de Agrela Pinto, C., Wu, Y., Boons, G.-J., Pabst, M., de Ridder, D. & Joo, C., 2024, In: Nature Nanotechnology. 19, 5, p. 652–659 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Genipin rescues developmental and degenerative defects in familial dysautonomia models and accelerates axon regeneration

Saito-Diaz, K., Dietrich, P., Saini, T., Rashid, M. M., Wu, H. F., Ishan, M., Sun, X., Bedillion, S., Patel, A. J., Prudden, A. R., Wzientek, C. G., Knight, T. N., Chen, Y. W., Boons, G. J., Chen, S., Studer, L., Tiemeyer, M., Xu, B., Dragatsis, I. & Liu, H. X. & 1 others, Zeltner, N., 20 Nov 2024, In: Science Translational Medicine. 16, 774, 16 p., eadq2418.

Research output: Contribution to journal › Article › Academic › peer-review

Glycoengineering with neuraminic acid analogs to label lipooligosaccharides and detect native sialyltransferase activity in gram-negative bacteria

Alvarado-Melendez, E. I., de Jong, H., Hartman, J. E. M., Ong, J. Y., Wösten, M. M. S. M. & Wennekes, T., 30 Aug 2024, In: Glycobiology. 34, 10, 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

H19 influenza A virus exhibits species-specific MHC class II receptor usage

Karakus, U., Mena, I., Kottur, J., El Zahed, S. S., Seoane, R., Yildiz, S., Chen, L., Plancarte, M., Lindsay, L., Halpin, R., Stockwell, T. B., Wentworth, D. E., Boons, G.-J., Krammer, F., Stertz, S., Boyce, W., de Vries, R. P., Aggarwal, A. K. & García-Sastre, A., 10 Jul 2024, In: Cell Host & Microbe. 32, 7, p. 1089-1102.e10

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Host defence peptide plectasin targets bacterial cell wall precursor lipid II by a calcium-sensitive supramolecular mechanism

Jekhmane, S., Derks, M. G. N., Maity, S., Slingerland, C. J., Tehrani, K. H. M. E., Medeiros-Silva, J., Charitou, V., Ammerlaan, D., Fetz, C., Consoli, N. A., Cochrane, R. V. K., Matheson, E. J., van der Weijde, M., Elenbaas, B. O. W., Lavore, F., Cox, R., Lorent, J. H., Baldus, M., Künzler, M. & Lelli, M. & 5 others, Cochrane, S. A., Martin, N. I., Roos, W. H., Breukink, E. & Weingarth, M., Jul 2024, In: Nature Microbiology. 9, 7, p. 1778-1791 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Human CD127 negative ILC2s show immunological memory

Mathä, L., Krabbendam, L., Martinez Høyer, S., Heesters, B. A., Golebski, K., Kradolfer, C., Ghaedi, M., Ma, J., Stadhouders, R., Bachert, C., Cardell, L.-O., Zhang, N., Holtappels, G., Reitsma, S., Helgers, L. C., Geijtenbeek, T. B. H., Coquet, J. M., Takei, F., Spits, H. & Martinez-Gonzalez, I., 5 Aug 2024, In: The Journal of experimental medicine. 221, 8, 22 p., e20231827.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Investigation of Human Milk as a Biological System in a Multicenter Mother-Infant Cohort: Protocol Design and Cohort Profile of the Phoenix Study

Phoenix Study Group, Wu, J., Gan, J., Zeng, G., Luo, X., Yang, N., Zhang, Z., Sun, Y., Shen, J., Wei, W., Yan, J., Zhu, J., Ludwig, T., Stahl, B., Zhao, X. & Wang, Z., 29 Aug 2024, In: Nutrients. 16, 17, 13 p., 2892.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Long-term evolution of human seasonal influenza virus A(H3N2) is associated with an increase in polymerase complex activity

Vigeveno, R. M., Han, A. X., de Vries, R. P., Parker, E., de Haan, K., van Leeuwen, S., Hulme, K. D., Lauring, A. S., Te Velthuis, A. J. W., Boons, G.-J., Fouchier, R. A. M., Russell, C. A., de Jong, M. D. & Eggink, D., 24 May 2024, In: Virus Evolution. 10, 1, 14 p., veae030.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Modulation of nucleotide metabolism by picornaviruses

Nouwen, L. V., Breeuwsma, M., Zaal, E. A., van de Lest, C. H. A., Buitendijk, I., Zwaagstra, M., Balić, P., Filippov, D. V., Berkers, C. R. & van Kuppeveld, F. J. M., Mar 2024, In: PLoS Pathogens. 20, 3 March, e1012036.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

Lin, C. P., Levy, P. L., Alflen, A., Apriamashvili, G., Ligtenberg, M. A., Vredevoogd, D. W., Bleijerveld, O. B., Alkan, F., Malka, Y., Hoekman, L., Markovits, E., George, A., Traets, J. J. H., Krijgsman, O., van Vliet, A., Poźniak, J., Pulido-Vicuña, C. A., de Bruijn, B., van Hal-van Veen, S. E. & Boshuizen, J. & 14 others, van der Helm, P. W., Díaz-Gómez, J., Warda, H., Behrens, L. M., Mardesic, P., Dehni, B., Visser, N. L., Marine, J. C., Markel, G., Faller, W. J., Altelaar, M., Agami, R., Besser, M. J. & Peeper, D. S., 8 Apr 2024, In: Cancer Cell. 42, 4, p. 623-645 23 p., e10.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Mustard seed major allergen Sin a1 activates intestinal epithelial cells and also dendritic cells that drive type 2 immune responses

Bueno-Díaz, C., Zuurveld, M., Ayechu-Muruzabal, V., Korsten, S. G. P. J., Martín-Pedraza, L., Parrón-Ballesteros, J., Redegeld, F., Garssen, J., Villalba, M. & Willemsen, L. E. M., Jun 2024, In: Food & function. 15, 12, p. 6488-6501 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Neural net analysis of NMR spectra from strongly-coupled spin systems

Prestegard, J. H., Boons, G. J., Chopra, P., Glushka, J., Grimes, J. H. & Simon, B., Nov 2024, In: Journal of Magnetic Resonance. 368, 107792.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Neuritogenic glycosaminoglycan hydrogels promote functional recovery after severe traumatic brain injury

Gonsalves, N., Sun, M. K., Chopra, P., Latchoumane, C.-F., Bajwa, S., Tang, R., Patel, B., Boons, G.-J. & Karumbaiah, L., 27 Jun 2024, In: Journal of neural engineering. 21, 3, 036058.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Oxygen-dependent regulation of F-box proteins in Toxoplasma gondii is mediated by Skp1 glycosylation

Mandalasi, M. N., Gas-Pascual, E., Baptista, C. G., Deng, B., van der Wel, H., Kruijtzer, J. A. W., Boons, G.-J., Blader, I. J. & West, C. M., Nov 2024, In: Journal of Biological Chemistry. 300, 11, 107801.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling

Unione, L., Ammerlaan, A. N. A., Bosman, G. P., Uslu, E., Liang, R., Broszeit, F., van der Woude, R., Liu, Y., Ma, S., Liu, L., Gómez-Redondo, M., Bermejo, I. A., Valverde, P., Diercks, T., Ardá, A., de Vries, R. P. & Boons, G. J., 6 Apr 2024, In: Nature Communications. 15, 1, 12 p., 2979.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Probing Peptidoglycan Synthesis in the Gut Commensal Akkermansia Muciniphila with Bioorthogonal Chemical Reporters

Sminia, T. J., Aalvink, S., de Jong, H., Tempelaars, M. H., Zuilhof, H., Abee, T., de Vos, W. M., Tytgat, H. L. P. & Wennekes, T., 1 Oct 2024, In: ChemBioChem. 25, 19, 10 p., e202400037.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Salivary polyreactive antibodies and Haemophilus influenzae are associated with respiratory infection severity in young children with recurrent respiratory infections

Koenen, M. H., de Steenhuijsen Piters, W. A. A., de Jonge, M. I., Langereis, J. D., Nierkens, S., Chu, M. L. J. N., van der Woude, R., de Vries, R. P., Sanders, E. A. M., Bogaert, D., van der Vries, E., Boes, M. & Verhagen, L. M., 1 Oct 2024, In: European Respiratory Journal . 64, 4, 18 p., e2400317.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Site-Specific Glyco-Tagging of Native Proteins for the Development of Biologicals

Gimeno, A., Ehlers, A. M., Delgado, S., Langenbach, J.-W. H., van den Bos, L. J., Kruijtzer, J. A. W., Guigas, B. G. A. & Boons, G.-J., 18 Dec 2024, In: Journal of the American Chemical Society. 146, 50, p. 34452-34465 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose

Xu, Y., Wang, X., Zaal, E. A., Berkers, C. R., Lorent, J. H., Heise, T., Cox, R., Pieters, R. J. & Breukink, E., May 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 4, 11 p., 159467.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Structure-Based Design and Synthesis of Lipid A Derivatives to Modulate Cytokine Responses

Verpalen, E. C. J. M., Brouwer, A. J., Wolfert, M. A. & Boons, G.-J., 6 Jun 2024, In: Chemistry-A European Journal. 30, 32, e202400429.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Structure dependent fermentation kinetics of dietary carrot rhamnogalacturonan-I in an in vitro gut model

Desai, K., Van den Abbeele, P., Duysburgh, C., Albers, R., Wennekes, T., Schols, H. A. & Mercenier, A., Aug 2024, In: Food Hydrocolloids. 153, p. 1-15 15 p., 110036.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Synthesis and biological evaluation of lipid A derived from commensal Bacteroides.

Verpalen, E. C. J. M., Ehlers, A. M., van Wingaarden, A. C. A., Brouwer, A. J. & Boons, G.-J., 28 Nov 2024, In: Organic & Biomolecular Chemistry. 22, 44, p. 8793-8800 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Synthetic glycans provide insight into the binding properties of toxic serum antibodies

Boons, G. J. & Jacobs, B. C., 1 Jan 2024, In: Nature Synthesis. 3, 1, p. 15-16 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Targeting N-Acetylglucosaminidase in Staphylococcus aureus with Iminosugar Inhibitors

Sluga, J., Tomašič, T., Anderluh, M., Rambaher, M. H., Bajc, G., Sevšek, A., Martin, N. I., Pieters, R. J., Novič, M. & Venko, K., Aug 2024, In: Antibiotics. 13, 8, 12 p., 751.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Chemical Biology and Drug Discovery

Research output

Search results