Research output per year
Research output per year
- 29 results
Search results
-
2025
Acanthamoeba castellanii trophozoites need oxygen for normal functioning and lipids are their preferred substrate, offering new possibilities for treatment
Sarink, M. J., Mykytyn, A. Z., Jedidi, A., Houweling, M., Brouwers, J. F., Ruijter, G., Verbon, A., van Hellemond, J. J. & Tielens, A. G. M., Jan 2025, In: International Journal for Parasitology. 55, 1, p. 35-44 10 p.Research output: Contribution to journal › Article › Academic › peer-review
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Cellular crosstalk promotes hepatic progenitor cell proliferation and stellate cell activation in 3D co-culture
Haaker, M. W., Chang, J.-C., Chung, B. K., Pieper, T. S., Noé, F., Wang, T., Geijsen, N., Houweling, M., Wolfrum, C., Vaandrager, A. B., Melum, E., Spee, B. & Helms, J. B., 2025, In: Cellular and Molecular Gastroenterology and Hepatology. 19, 5, 101472.Research output: Contribution to journal › Article › Academic › peer-review
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Metabolic profiling of patient-derived organoids reveals nucleotide synthesis as a metabolic vulnerability in malignant rhabdoid tumors
Kes, M. M. G., Morales-Rodriguez, F., Zaal, E. A., de Souza, T., Proost, N., van de Ven, M., van den Heuvel-Eibrink, M. M., Jansen, J. W. A., Berkers, C. R. & Drost, J., 21 Jan 2025, In: Cell Reports Medicine. 6, 1, 101878.Research output: Contribution to journal › Article › Academic › peer-review
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Rationally designed peptides inhibit the formation of α-synuclein fibrils and oligomers
Ali, T. T., Merghani, M., Al-Azzani, M., Gatzemeier, L. M., Hoppert, M., Kaloyanova, D., Outeiro, T. F., Neumann, P., Popova, B. & Braus, G. H., 5 May 2025, In: European Journal of Medicinal Chemistry. 289, 14 p., 117452.Research output: Contribution to journal › Article › Academic › peer-review
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Stable Isotope Tracing Experiments Using LC-MS
Zaal, E. A., Jansen, J. W. A. & Berkers, C. R., 2025, In: Methods in molecular biology (Clifton, N.J.). 2855, p. 103-116 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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2024
AMPK activation induces RALDH+ tolerogenic dendritic cells by rewiring glucose and lipid metabolism
Brombacher, E. C., Patente, T. A., van der Ham, A. J., Moll, T. J. A., Otto, F., Verheijen, F. W. M., Zaal, E. A., de Ru, A. H., Tjokrodirijo, R. T. N., Berkers, C. R., van Veelen, P. A., Guigas, B. & Everts, B., 7 Oct 2024, In: The Journal of cell biology. 223, 10, e202401024.Research output: Contribution to journal › Article › Academic › peer-review
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Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants
Yang, C., Pataskar, A., Feng, X., Montenegro Navarro, J., Paniagua, I., Jacobs, J. J. L., Zaal, E. A., Berkers, C. R., Bleijerveld, O. B. & Agami, R., 16 May 2024, In: Molecular Cell. 84, 10, p. 1904-1916.e7Research output: Contribution to journal › Article › Academic › peer-review
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Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection
Veth, T. S., Nouwen, L. V., Zwaagstra, M., Lyoo, H., Wierenga, K. A., Westendorp, B., Altelaar, M. A. F. M., Berkers, C., van Kuppeveld, F. J. M. & Heck, A. J. R., May 2024, In: Molecular and Cellular Proteomics. 23, 5, 100757.Research output: Contribution to journal › Article › Academic › peer-review
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Early activation of hepatic stellate cells induces rapid initiation of retinyl ester breakdown while maintaining lecithin: Retinol acyltransferase (LRAT) activity
Haaker, M. W., Goossens, V., Hoogland, N. A. N., van Doorne, H., Wang, Z., Jansen, J. W. A., Kaloyanova, D. V., van de Lest, C. H. A., Houweling, M., Vaandrager, A. B. & Helms, J. B., Oct 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 7, 10 p., 159540.Research output: Contribution to journal › Article › Academic › peer-review
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ER stress inhibition enhances formation of triacylglcerols and protects endothelial cells from lipotoxicity
Kovacevic, I., Schmidt, P. H., Kowalski, A., Helms, B. J., Lest, C. H. A. V. D., Kluttig, A. & Posern, G., 3 Jun 2024, In: Cell Communication and Signaling. 22, 1, p. 1-21 21 p., 304.Research output: Contribution to journal › Article › Academic › peer-review
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Extracellular vesicles from seminal plasma interact with T cells in vitro and drive their differentiation into regulatory T-cells
Zhang, X., Greve, P. F., Minh, T. T. N., Wubbolts, R., Demir, A. Y., Zaal, E. A., Berkers, C. R., Boes, M. & Stoorvogel, W., Jul 2024, In: Journal of Extracellular Vesicles. 13, 7, p. 1-22 22 p., e12457.Research output: Contribution to journal › Article › Academic › peer-review
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Immune suppression by human thymus-derived effector Tregs relies on glucose/lactate-fueled fatty acid synthesis
de Kivit, S., Mensink, M., Kostidis, S., Derks, R. J. E., Zaal, E. A., Heijink, M., Verleng, L. J., de Vries, E., Schrama, E., Blomberg, N., Berkers, C. R., Giera, M. & Borst, J., 24 Sept 2024, In: Cell Reports. 43, 9, 114681.Research output: Contribution to journal › Article › Academic › peer-review
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Intracellular localisation and extracellular release of Y RNA and Y RNA binding proteins
Driedonks, T. A. P., Ressel, S., Tran Ngoc Minh, T., Buck, A. H. & Nolte-‘t Hoen, E. N. M., Jan 2024, In: Journal of Extracellular Biology. 3, 1, 16 p., e123.Research output: Contribution to journal › Article › Academic › peer-review
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KCNJ16-depleted kidney organoids recapitulate tubulopathy and lipid recovery upon statins treatment
Sendino Garví, E., van Slobbe, G. J. J., Zaal, E. A., de Baaij, J. H. F., Hoenderop, J. G., Masereeuw, R., Janssen, M. J. & van Genderen, A. M., 26 Aug 2024, In: Stem cell research & therapy. 15, 1, 268.Research output: Contribution to journal › Article › Academic › peer-review
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Lipidome profiling of neutrophil-derived extracellular vesicles unveils their contribution to the ensemble of synovial fluid-derived extracellular vesicles during joint inflammation
Varela, L., Mol, S., Taanman-Kueter, E. W., Ryan, S. E., Taams, L. S., de Jong, E., van Weeren, P. R., van de Lest, C. H. A. & Wauben, M. H. M., Oct 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 7, 159534.Research output: Contribution to journal › Article › Academic › peer-review
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Modulation of nucleotide metabolism by picornaviruses
Nouwen, L. V., Breeuwsma, M., Zaal, E. A., van de Lest, C. H. A., Buitendijk, I., Zwaagstra, M., Balić, P., Filippov, D. V., Berkers, C. R. & van Kuppeveld, F. J. M., Mar 2024, In: PLoS Pathogens. 20, 3 March, e1012036.Research output: Contribution to journal › Article › Academic › peer-review
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Oleic acid enhances proliferation and calcium mobilization of CD3/CD28 activated CD4+ T cells through incorporation into membrane lipids
von Hegedus, J. H., de Jong, A. J., Hoekstra, A. T., Spronsen, E., Zhu, W., Cabukusta, B., Kwekkeboom, J. C., Heijink, M., Bos, E., Berkers, C. R., Giera, M. A., Toes, R. E. M. & Ioan-Facsinay, A., Sept 2024, In: European Journal of Immunology. 54, 9, 2350685.Research output: Contribution to journal › Article › Academic › peer-review
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Oral β-RA induces metabolic rewiring leading to the rescue of diet-induced obesity
Díaz-Casado, M. E., González-García, P., López-Herrador, S., Hidalgo-Gutiérrez, A., Jiménez-Sánchez, L., Barriocanal-Casado, E., Bakkali, M., van de Lest, C. H. A., Corral-Sarasa, J., Zaal, E. A., Berkers, C. R. & López, L. C., 1 Oct 2024, In: Biochimica et Biophysica Acta. Molecular Basis of Disease. 1870, 7, 14 p., 167283.Research output: Contribution to journal › Article › Academic › peer-review
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P53-dependent hypusination of eIF5A affects mitochondrial translation and senescence immune surveillance
Jiang, X., Baig, A. H., Palazzo, G., Del Pizzo, R., Bortecen, T., Groessl, S., Zaal, E. A., Amaya Ramirez, C. C., Kowar, A., Aviles-Huerta, D., Berkers, C. R., Palm, W., Tschaharganeh, D., Krijgsveld, J. & Loayza-Puch, F., 28 Aug 2024, In: Nature Communications. 15, 1, 16 p., 7458.Research output: Contribution to journal › Article › Academic › peer-review
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Proteome and phospholipidome interrelationship of synovial fluid-derived extracellular vesicles in equine osteoarthritis: An exploratory 'multi-omics' study to identify composite biomarkers
Clarke, E., Varela, L., Jenkins, R. E., Lozano-Andrés, E., Cywińska, A., Przewozny, M., van Weeren, P. R., van de Lest, C. H. A., Peffers, M. & Wauben, M. H. M., Mar 2024, In: Biochemistry and Biophysics Reports. 37, 15 p., 101635.Research output: Contribution to journal › Article › Academic › peer-review
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S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma
Wang, Y., Muylaert, C., Wyns, A., Vlummens, P., De Veirman, K., Vanderkerken, K., Zaal, E., Berkers, C., Moreaux, J., De Bruyne, E. & Menu, E., 1 Jan 2024, In: Haematologica. 109, 1, p. 256-271 16 p.Research output: Contribution to journal › Article › Academic › peer-review
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Specific labeling of newly synthesized lipopolysaccharide via metabolic incorporation of azido-galactose
Xu, Y., Wang, X., Zaal, E. A., Berkers, C. R., Lorent, J. H., Heise, T., Cox, R., Pieters, R. J. & Breukink, E., May 2024, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1869, 4, 11 p., 159467.Research output: Contribution to journal › Article › Academic › peer-review
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The unusual kinetics of lactate dehydrogenase of Schistosoma mansoni and their role in the rapid metabolic switch after penetration of the mammalian host
Bexkens, M. L., Martin, O. M. F., van den Heuvel, J. M., Schmitz, M. G. J., Teusink, B., Bakker, B. M., van Hellemond, J. J., Haanstra, J. R., Walkinshaw, M. D. & Tielens, A. G. M., Jun 2024, In: International Journal for Parasitology. 54, 7, p. 367-378 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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2023
Acute joint inflammation induces a sharp increase in the number of synovial fluid EVs and modifies their phospholipid profile
Varela, L., van de Lest, C. H. A., Boere, J., Libregts, S. F. W. M., Lozano-Andrés, E., van Weeren, P. R. & Wauben, M. H. M., Oct 2023, In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1868, 10, 13 p., 159367.Research output: Contribution to journal › Article › Academic › peer-review
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Characterization of acrosin and acrosin binding protein as novel CRISP2 interacting proteins in boar spermatozoa
Zhang, M., Chiozzi, R. Z., Bromfield, E. G., Heck, A. J., Helms, J. B. & Gadella, B. M., Oct 2023, In: Andrology. 11, 7, p. 1460-1471 12 p.Research output: Contribution to journal › Article › Academic › peer-review
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Hyperlipidaemia elicits an atypical, T helper 1-like CD4 + T-cell response: a key role for very low-density lipoprotein.
van Os, B. W., Vos, W. G., Bosmans, L. A., van Tiel, C. M., Lith, S. C., den Toom, M. S., Beckers, L., Levels, J. H. M., van Wouw, S. A. E., Zelcer, N., Zaal, E. A., Berkers, C. R., van der Lest, C. H. A., Helms, J. B., Weber, C., Atzler, D., de Winther, M. P. J., Baardman, J. & Lutgens, E., Mar 2023, In: European Heart Journal Open. 3, 2, p. 1-14 14 p., oead013.Research output: Contribution to journal › Article › Academic › peer-review
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Lipidomic profiling of rat hepatic stellate cells during activation reveals a two-stage process accompanied by increased levels of lysosomal lipids
Molenaar, M. R., Haaker, M. W., Vaandrager, A. B., Houweling, M. & Helms, J. B., Apr 2023, In: Journal of Biological Chemistry. 299, 4, 14 p., 103042.Research output: Contribution to journal › Article › Academic › peer-review
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Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury
Faria, J., Calcat-i-Cervera, S., Skovronova, R., Broeksma, B. C., Berends, A. J., Zaal, E. A., Bussolati, B., O’Brien, T., Mihăilă, S. M. & Masereeuw, R., 10 Dec 2023, In: Stem cell research & therapy. 14, 1, p. 1-19 19 p., 353.Research output: Contribution to journal › Article › Academic › peer-review
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Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment
Matamala Montoya, M., van Slobbe, G. J. J., Chang, J.-C., Zaal, E. A. & Berkers, C. R., 6 Apr 2023, In: Frontiers in Oncology. 13, 9 p., 1155621.Research output: Contribution to journal › Article › Academic › peer-review
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