Biomolecular Mass Spectrometry and Proteomics

2025

Acquisition of Fc-afucosylation of PfEMP1-specific IgG is age-dependent and associated with clinical protection against malaria

Lopez-Perez, M., Seidu, Z., Larsen, M. D., Wang, W., Nouta, J., Wuhrer, M., Vidarsson, G., Ofori, M. F. & Hviid, L., 2 Jan 2025, In: Nature Communications. 16, 1, 237.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Affinity-based covalent sialyltransferase probes enabled by ligand-directed chemistry

Ong, J. Y., Alvarado-Melendez, E. I., Maliepaard, J. C. L., Reiding, K. R. & Wennekes, T., 21 Feb 2025, In: Chemical Science. 16, 7, p. 3336-3344 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Bisecting N-Acetylglucosamine of the N-Glycan of Immunoglobulin G Does Not Affect Binding to Fc Gamma Receptors

Bosman, G. P., Stoof, I. D., Bastiaansen, H. P., Quarles van Ufford, L., Dobruchowska, J. M., Langenbach, J. W. H., Boruah, B. M., Moremen, K. W., Bentlage, A. E. H., Lissenberg-Thunnissen, S. N., Vidarsson, G. & Boons, G. J., 21 Mar 2025, In: ACS Chemical Biology. 20, 3, p. 680-689 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

Strijker, J. G. M., Pascual-Pasto, G., Grothusen, G. P., Kalmeijer, Y. J., Kalaitsidou, E., Zhao, C., McIntyre, B., Matlaga, S., Visser, L. L., Barisa, M., Himsworth, C., Shah, R., Muller, H., Schild, L. G., Hains, P. G., Zhong, Q., Reddel, R. R., Robinson, P. J., Catena, X. & Soengas, M. S. & 7 others, Margaritis, T., Dekker, F. J., Anderson, J., Molenaar, J. J., Bosse, K. R., Wu, W. & Wienke, J., 11 Mar 2025, In: European Journal of Cancer. 218, 115263.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition

Timmer, L. T., den Hertog, E., Versteeg, D., Post, H., Verdonschot, J. A. J., Monshouwer-Kloots, J., Kyriakopoulou, E., Perini, I., Koopmans, T., van der Kraak, P., Zentilin, L., Heymans, S. R. B., Vink, A., Giacca, M., Heck, A. J. R. & van Rooij, E., 17 Feb 2025, (E-pub ahead of print) In: Cardiovascular Research. 16 p., cvaf021.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends

Iyer, S. S., Chen, F., Ogunmolu, F. E., Moradi, S., Volkov, V. A., van Grinsven, E. J., van Hoorn, C., Wu, J., Andrea, N., Hua, S., Jiang, K., Vakonakis, I., Potočnjak, M., Herzog, F., Gigant, B., Gudimchuk, N., Stecker, K. E., Dogterom, M., Steinmetz, M. O. & Akhmanova, A., 3 Mar 2025, In: The Journal of cell biology. 224, 3, 36 p., e202406061.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Correction to: π-HuB: the proteomic navigator of the human body (Nature, (2024), 636, 8042, (322-331), 10.1038/s41586-024-08280-5)

The π-HuB Consortium, He, F., Aebersold, R., Baker, M. S., Bian, X., Bo, X., Chan, D. W., Chang, C., Chen, L., Chen, X., Chen, Y. J., Cheng, H., Collins, B. C., Corrales, F., Cox, J., E, W., Van Eyk, J. E., Fan, J., Faridi, P. & Figeys, D. & 31 others, Gao, G. F., Gao, W., Gao, Z. H., Goda, K., Goh, W. W. B., Gu, D., Guo, C., Guo, T., He, Y., Heck, A. J. R., Hermjakob, H., Hunter, T., Iyer, N. G., Jiang, Y., Jimenez, C. R., Joshi, L., Kelleher, N. L., Li, M., Li, Y., Lin, Q., Liu, C. H., Liu, F., Liu, G. H., Liu, Y., Liu, Z., Low, T. Y., Lu, B., Mann, M., Meng, A., Moritz, R. L. & Nice, E., 2025, In: Nature. 637, 8046, p. E22

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Engineering of anticancer human immunoglobulin A equipped with albumin for enhanced plasma half-life

Mester, S., Chan, C., Lustig, M., Foss, S., Jansen, J. H. M., Herigstad, M. L., Evers, M., Nilsen, J., Reiding, K. R., Damen, J. M. A., Burger, R., Grevys, A., Dalhus, B., Valerius, T., Sandlie, I., Leusen, J. H. W. & Andersen, J. T., 28 Feb 2025, In: PNAS Nexus. 4, 2, 16 p., pgaf042.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Exploring Uncharted Territories in Immunoglobulomics: Comprehensive Profiling of Human Antibody Repertoires in Blood Using Mass Spectrometry

van Rijswijck, D. M. H., 29 Jan 2025, Utrecht: Utrecht University. 211 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

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Human Milk Feeding in Inherited Metabolic Disorders: A Systematic Review of Growth, Metabolic Control, and Neurodevelopment Outcomes

Ilgaz, F., Höller, A., Marsaux, C., Banta-Wright, S., Coşkun, T., Dingess, K. A., Jörg-Streller, M., Newby, C., Singh, R., Stahl, B., Szwec, C., van Wegberg, A., Woestenenk, W., MacDonald, A. & Karall, D., Mar 2025, In: Journal of Inherited Metabolic Disease. 48, 2, 23 p., e70001.

Research output: Contribution to journal › Review article › peer-review

Open Access

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In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer

Jager, S., Zeller, M., Pashkova, A., Schulte, D., Damoc, E., Reiding, K. R., Makarov, A. A. & Heck, A. J. R., 13 Mar 2025, In: Nature Communications. 16, 1, 2497.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial

Nurmi, V., Mayne, R., Knight, C., Almonacid-Mendoza, H. L., Secret, S., Estcourt, L., Hepojoki, J., Šuštić, T., Lamikanra, A. A., Tsang, H. P., Menon, D. K., Shankar-Hari, M., van der Schoot, C. E., Vidarsson, G., Roberts, D. J., Simmonds, P., Hedman, K. & Harvala, H., Feb 2025, In: Journal Of Infection. 90, 2, 106412.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Local structural flexibility drives oligomorphism in computationally designed protein assemblies

Khmelinskaia, A., Bethel, N. P., Fatehi, F., Mallik, B. B., Antanasijevic, A., Borst, A. J., Lai, S.-H., Chim, H. Y., Wang, J. Y. '., Miranda, M. C., Watkins, A. M., Ogohara, C., Caldwell, S., Wu, M., Heck, A. J. R., Veesler, D., Ward, A. B., Baker, D., Twarock, R. & King, N. P., 26 Feb 2025, (E-pub ahead of print) In: Nature Structural and Molecular Biology. 746.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Multitiered Proteome Analysis Displays the Hyperpermeability of the Rheumatoid Synovial Compartment for Plasma Proteins

Stork, E. M., Nteak, S. K., van Rijswijck, D. M. H., Damen, J. M. A., Scherer, H. U., Toes, R. E. M., Bondt, A., Huizinga, T. W. J. & Heck, A. J. R., Feb 2025, In: Molecular and Cellular Proteomics. 24, 2, 14 p., 100900.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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NAC regulates metabolism and cell fate in intestinal stem cells

Ramalho, S., Alkan, F., Prekovic, S., Jastrzebski, K., Barberà, E. P., Hoekman, L., Altelaar, M., de Heus, C., Liv, N., Rodríguez-Colman, M. J., Yilmaz, M., van der Kammen, R., Fedry, J., de Gooijer, M. C., Suijkerbuijk, S. J. E., Faller, W. J. & Silva, J., 10 Jan 2025, In: Science advances. 11, 2, eadn9750.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Profiles of 71 Human Milk Oligosaccharides and Novel Sub-Clusters of Type I Milk: Results from the Ulm SPATZ Health Study

Peng, Z., Siziba, L. P., Mank, M., Stahl, B., Gonsalves, J., Wernecke, D., Rothenbacher, D. & Genuneit, J., 14 Jan 2025, In: Nutrients. 17, 2, 280.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Prolonged Trapping of Adeno-Associated Virus Capsids Reveals that Genome Packaging Affects Single-Ion Mass Spectrometry Measurements

Ebberink, E. H. T. M., Yin, V. C., Deslignière, E., Barendregt, A., Wörner, T. P., Fort, K. L., Makarov, A. A. & Heck, A. J. R., 2 Apr 2025, In: Journal of the American Chemical Society. 147, 13, p. 10925-10934 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Protein-bound and free glycation compounds in human milk: A comparative study with minimally processed infant formula and pasteurized bovine milk

Arena, S., De Pascale, S., Ciaravolo, V., Monroy, M. M., Gouw, J. W., Stahl, B., Bäuerl, C., Collado, M. C., De Filippo, C., Scaloni, A. & Troise, A. D., 15 Jan 2025, In: Food Chemistry. 463, Pt 2, 14 p., 141265.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Robust and High-Resolution All-Ion Fragmentation LC-ESI-IM-MS Analysis for In-Depth Characterization or Profiling of Up to 200 Human Milk Oligosaccharides

Gonsalves, J., Bauzá-Martinez, J., Stahl, B., Dingess, K. A. & Mank, M., 18 Mar 2025, In: Analytical Chemistry. 97, 10, p. 5563-5574 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Spatial organization of the sperm cell glycoproteome

Ji, R., Chiozzi, R. Z., van den Toorn, H., Leung, M., Zeev-Ben-Mordehai, T., Burke, N. D., Bromfield, E. G., Reiding, K. R. & Heck, A. J. R., Jan 2025, In: Molecular and Cellular Proteomics. 24, 1, 100893.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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2024

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

Reinisch, I., Michenthaler, H., Sulaj, A., Moyschewitz, E., Krstic, J., Galhuber, M., Xu, R., Riahi, Z., Wang, T., Vujic, N., Amor, M., Zenezini Chiozzi, R., Wabitsch, M., Kolb, D., Georgiadi, A., Glawitsch, L., Heitzer, E., Schulz, T. J., Schupp, M. & Sun, W. & 11 others, Dong, H., Ghosh, A., Hoffmann, A., Kratky, D., Hinte, L. C., von Meyenn, F., Heck, A. J. R., Blüher, M., Herzig, S., Wolfrum, C. & Prokesch, A., 15 Feb 2024, In: Nature Communications. 15, 1, p. 1-21 21 p., 1391.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Afucosylated broadly neutralizing antibodies enhance clearance of HIV-1 infected cells through cell-mediated killing

de Taeye, S. W., Schriek, A. I., Umotoy, J. C., Grobben, M., Burger, J. A., Sanders, R. W., Vidarsson, G., Wuhrer, M., Falck, D., Kootstra, N. A. & van Gils, M. J., 9 Aug 2024, In: Communications Biology. 7, 1, 11 p., 964.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

Stork, E. M., van Rijswijck, D. M. H., van Schie, K. A., Hoek, M., Kissel, T., Scherer, H. U., Huizinga, T. W. J., Heck, A. J. R., Toes, R. E. M. & Bondt, A., 10 Apr 2024, In: Nature Communications. 15, 1, 12 p., 3114.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Assessment of IgG-Fc glycosylation from individual RhD-specific B cell clones reveals regulation at clonal rather than clonotypic level

de Graaf, E. L., Larsen, M. D., van der Bolt, N., Visser, R., Verhagen, O. J. H. M., Hipgrave Ederveen, A. L., Koeleman, C. A. M., van der Schoot, C. E., Wuhrer, M. & Vidarsson, G., Mar 2024, In: Immunology. 171, 3, p. 428-439 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection

Veth, T. S., Nouwen, L. V., Zwaagstra, M., Lyoo, H., Wierenga, K. A., Westendorp, B., Altelaar, M. A. F. M., Berkers, C., van Kuppeveld, F. J. M. & Heck, A. J. R., May 2024, In: Molecular and Cellular Proteomics. 23, 5, 100757.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Asymmetric N-Glycosylation in the Tailpiece of Recombinant IgA1.

Peris-Díaz, M. D., Deslignière, E., Jager, S., Mokiem, N., Barendregt, A., Bondt, A. & Heck, A. J. R., 18 Dec 2024, In: Journal of the American Chemical Society. 146, 50, p. 34720-34732 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions

Koppers, M., Özkan, N., Nguyen, H. H., Jurriens, D., McCaughey, J., Nguyen, D. T. M., Li, C. H., Stucchi, R., Altelaar, M., MacGillavry, H. D., Kapitein, L. C., Hoogenraad, C. C. & Farías, G. G., 19 Aug 2024, In: Developmental Cell. 59, 16, p. 2053-2068.e9 26 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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CAMSAPs and nucleation-promoting factors control microtubule release from γ-TuRC

Rai, D., Song, Y., Hua, S., Stecker, K., Monster, J. L., Yin, V., Stucchi, R., Xu, Y., Zhang, Y., Chen, F., Katrukha, E. A., Altelaar, M., Heck, A. J. R., Wieczorek, M., Jiang, K. & Akhmanova, A., Mar 2024, In: Nature Cell Biology. 26, 3, p. 404-420 17 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Complex N-glycans are important for interspecies transmission of H7 influenza A viruses

Spruit, C. M., Palme, D. I., Li, T., Ríos Carrasco, M., Gabarroca García, A., Sweet, I. R., Kuryshko, M., Maliepaard, J. C. L., Reiding, K. R., Scheibner, D., Boons, G.-J., Abdelwhab, E. M. & de Vries, R. P., Apr 2024, In: Journal of Virology. 98, 4, 21 p., e0194123.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Computational Approaches for Mass Spectrometry-based Characterization of Antibody Repertoires

de Graaf, S., 25 Mar 2024, Utrecht University. 223 p.

Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

Open Access

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Contactin 2 homophilic adhesion structure and conformational plasticity

Chataigner, L. M. P., Thärichen, L., Beugelink, J. W., Granneman, J. C. M., Mokiem, N. J., Snijder, J., Förster, F. & Janssen, B. J. C., 4 Jan 2024, In: Structure. 32, 1, p. 60-73.e5

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-Based Sortase A-Mediated Ligation of T-Cell Epitopes

Wang, A. Z., Brink, H. J., Bouma, R. G., Affandi, A. J., Nijen Twilhaar, M. K., Heijnen, D. A. M., van Elk, J., Maaskant, J. J., Konijn, V. A. L., Stolwijk, J. G. C., Kalay, H., Olesek, K., van Kooyk, Y., van der Schoot, J. M. S., Bentlage, A. E. H., Scheeren, F. A., Verdoes, M., Vidarsson, G., Kuijl, C. P. & den Haan, J. M. M., 20 Nov 2024, In: Bioconjugate Chemistry. 35, 11, p. 1805-1814 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Direct Comparison of the Hinge-Cleaving Proteases IgdE and BdpK for LC-MS-Based IgG1 Clonal Profiling

van Rijswijck, D. M. H., Bondt, A., de Kat, N., Lood, R. & Heck, A. J. R., 9 Jan 2024, In: Analytical Chemistry. 96, 1, p. 23-27 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs

van Bergen, W., Zuna, K., Fiala, J., Pohl, E. E., Heck, A. J. R. & Baggelaar, M. P., 16 Aug 2024, In: ACS Chemical Biology. 19, 8, p. 1705-1718 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair

Shah, R., Aslam, M. A., Spanjaard, A., de Groot, D., Zurcher, L. M., Altelaar, M., Hoekman, L., Pritchard, C. E. J., Pilzecker, B., van den Berk, P. C. M. & Jacobs, H., 2 Jul 2024, In: PNAS Nexus. 3, 7, 14 p., pgae242.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7

Boretto, M., Geurts, M. H., Gandhi, S., Ma, Z., Staliarova, N., Celotti, M., Lim, S., He, G. W., Millen, R., Driehuis, E., Begthel, H., Smabers, L., Roodhart, J., van Es, J., Wu, W. & Clevers, H., 19 Mar 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 12, e2309902121.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Fast and Accurate Disulfide Bridge Detection

Heissel, S., He, Y., Jankevics, A., Shi, Y., Molina, H., Viner, R. & Scheltema, R. A., May 2024, In: Molecular and Cellular Proteomics. 23, 5, 12 p., 100759.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Fc glycosylation of alloantibodies in platelet refractoriness

van Osch, T. L. J., 6 Feb 2024, Utrecht: Utrecht University. 183 p.

Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

Open Access

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Gene and protein sequence features augment HLA class I ligand predictions

Bresser, K., Nicolet, B. P., Jeko, A., Wu, W., Loayza-Puch, F., Agami, R., Heck, A. J. R., Wolkers, M. C. & Schumacher, T. N., 11 Jun 2024, In: Cell Reports. 43, 6, 23 p., 114325.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Gene and protein sequence features augment HLA class I ligand predictions

Bresser, K., Nicolet, B. P., Jeko, A., Wu, W., Loayza-Puch, F., Agami, R., Heck, A. J. R., Wolkers, M. C. & Schumacher, T. N., 23 Jul 2024, In: Cell Reports. 43, 7, 114418.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Open Access

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Generation of human antibodies targeting human platelet antigen (HPA)-1a

Oosterhoff, J. J., Linty, F., Visser, R., de Vos, T., Hofstede-van Egmond, S., van de Weerd, M., Porcelijn, L., de Haas, M., van der Schoot, E. & Vidarsson, G., May 2024, In: Transfusion. 64, 5, p. 893-905 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Genotype-dependent N-glycosylation and newly exposed O-glycosylation affect plasmin-induced cleavage of histidine-rich glycoprotein (HRG)

Zou, Y., Pronker, M. F., Damen, J. M. A., Heck, A. J. R. & Reiding, K. R., Jan 2024, In: Journal of Biological Chemistry. 300, 3, 12 p., 105683.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Higher-order structure and proteoforms of co-occurring C4b-binding protein assemblies in human serum

Kadavá, T., Hevler, J. F., Kalaidopoulou Nteak, S., Yin, V. C., Strasser, J., Preiner, J. & Heck, A. J. R., Jul 2024, In: EMBO Journal. 43, 14, p. 3009-3026 18 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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High throughput screening identifies repurposable drugs for modulation of innate and acquired immune responses

Ghorbanalipoor, S., Matsumoto, K., Gross, N., Heimberg, L., Krause, M., Veldkamp, W., Magens, M., Zanken, J., Neuschutz, K. J., De Luca, D. A., Kridin, K., Vidarsson, G., Chakievska, L., Visser, R., Kunzel, S., Recke, A., Gupta, Y., Boch, K., Vorobyev, A. & Kalies, K. & 3 others, Manz, R. A., Bieber, K. & Ludwig, R. J., Sept 2024, In: Journal of Autoimmunity. 148, 15 p., 103302.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Human fetal brain self-organizes into long-term expanding organoids

Hendriks, D., Pagliaro, A., Andreatta, F., Ma, Z., van Giessen, J., Massalini, S., López-Iglesias, C., van Son, G. J. F., DeMartino, J., Damen, J. M. A., Zoutendijk, I., Staliarova, N., Bredenoord, A. L., Holstege, F. C. P., Peters, P. J., Margaritis, T., Chuva de Sousa Lopes, S., Wu, W., Clevers, H. & Artegiani, B., 1 Feb 2024, In: Cell. 187, 3, p. 712-732 21 p., e38.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Human IgG Subclasses Differ in the Structural Elements of Their N-Glycosylation

Wang, W., Maliepaard, J. C. L., Damelang, T., Vidarsson, G., Heck, A. J. R. & Reiding, K. R., 27 Nov 2024, In: ACS Central Science. 10, 11, p. 2048-2058 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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IgG1 glycosylation highlights premature aging in Down syndrome

Streng, B., Van Coillie, J., Wildenbeest, J., Binnendijk, R., Smits, G., den Hartog, G., Wang, W., Nouta, J., Linty, F., Visser, R., Wuhrer, M., Vidarsson, G. & Bont, L., Jul 2024, In: Aging Cell. 23, 7, 10 p., e14167.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Impact of structural modifications of IgG antibodies on effector functions

Damelang, T., Brinkhaus, M., van Osch, T., Schuurman, J., Labrijn, A., Rispens, T. & Vidarsson, G., 8 Jan 2024, In: Frontiers in Immunology. 14, 25 p., 1304365.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Inceptor binds to and directs insulin towards lysosomal degradation in β cells

Siehler, J., Bilekova, S., Chapouton, P., Dema, A., Albanese, P., Tamara, S., Jain, C., Sterr, M., Enos, S. J., Chen, C., Malhotra, C., Villalba, A., Schomann, L., Bhattacharya, S., Feng, J., Akgün Canan, M., Ribaudo, F., Ansarullah, Burtscher, I. & Ahlbrecht, C. & 6 others, Plettenburg, O., Kurth, T., Scharfmann, R., Speier, S., Scheltema, R. A. & Lickert, H., 2024, In: Nature Metabolism. 6, 12, p. 2374–2390 17 p., e202206132.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Innovative strategies for measuring kinase activity to accelerate the next wave of novel kinase inhibitors

Veth, T. S., Kannegieter, N. M., de Graaf, E. L., Ruijtenbeek, R., Joore, J., Ressa, A. & Altelaar, M., Mar 2024, In: Drug Discovery Today. 29, 3, p. 1-11 11 p., 103907.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Biomolecular Mass Spectrometry and Proteomics

Research output

Search results