Description
NIMBioS Working Group: Within-host modeling of MAP infectionsThe NIMBioS working group on mathematical modeling of the within-host response to a Mycobacterium avium subsp paratuberculosis (MAP) infection is a logical consequence of a very successful NIMBioS investigative workshop on MAP held in the summer of 2011. This workshop highlighted the current state of our knowledge and clearly identified our lack of understanding of the within-host infection process of MAP. Empirical data on infection progression is present and multiple distinct infection patterns are present in MAP infected cattle. However, the immunological and microbiological attributes of infection and disease patterns are not well understood. There is a large amount of piece-meal immunological data available in previous publications and in the hands of MAP scientists. However these data have not resulted in a comprehensive understanding of the infection process. The objective of this working group is to develop a within-host MAP infection model, using observational data on infection patterns and within-host immune response data. The ultimate goal of the model is to provide an understanding of progression of disease in response to MAP infection and to devise better mitigation strategies for Johne's disease.
| Period | 2011 → 2015 |
|---|---|
| Held at | NIMBioS National Institute for Integration of Mathematical and Biological Sciences, United States |