Activity: Talk or presentation › Invited talk › Academic
Description
There has been a documented rise in the incidence of cancers diagnosed prior to the age of 50, a phenomenon that has coincided with global changes since the mid-20th century. These are designated as 'early-onset cancers' (EOC), and are hypothesized to result from the accumulative exposures and biological reactions that constitute the 'exposome.' Increasing evidence points to the possibility that the etiology of these cancers may originate in early life. The vast array and heterogeneity of factors, including alterations in the food supply, use of antibiotics and other medications, health behaviors, exposure to pesticides and various environmental chemicals, present a challenge for precise hypothesis testing. In Exposome research, novel technological advances have been made to enhance the measurement of the exposome. These advancements facilitate a discovery-driven approach to identifying the environmental bases of cancer. Such methodologies hold promise not only for elucidating the environmental roots of adult cancer but may also be applicable in the context of pediatric cancer.